DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-130

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_503993.3	Gene:	srw-130 / 188831	WormBaseID:	WBGene00005877	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	81/388 - (20%)
Similarity:	152/388 - (39%)	Gaps:	93/388 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SDPSHGFGEEDYACGTFNCSPKEFV----AFVLGPQTLPLYKAVLITIIFGGIFITGVVGNLLVC 90
            ||....|...|.:.....|..:|||    :.:|.      |::.:....|   ||     |:...
Worm     8 SDLDFCFPGYDKSTALAYCDFQEFVEKFSSRILN------YESYISVASF---FI-----NIFHF 58

  Fly    91 IVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYW-----------HQYPDLFGMPFCKI 144
            |::.|.....::.|..:.::|:.::|.|.:...|.: |||           .....|..:.|.|:
Worm    59 IILTRKPIRTSSVNIIMTAIAIVEILSLFYNFKTSI-LYWLRTNYKCFNSNSHASVLIDLCFIKL 122

  Fly   145 RAFISEACTYVSVFTIVAFSMERFLAICHPL-HLYAMVGFKRAIRIITALWIVSFISAIPFGLLS 208
            |.| :..|   |.:..::.:|.|.|.|.:|: ..:..:...||..::.            ||:||
Worm   123 RDF-ARRC---SPWLCLSIAMIRALVIRNPMSQKFEKLSMPRASVVVI------------FGILS 171

  Fly   209 -----DI-QYLNYPLDH-------SRIEESAFCSMSPKIVNE-----IPVFEVS-FCIFFVIPMI 254
                 || .:..|.:..       |:.::..:..:..|:.::     |.::..| ..|..:||.|
Worm   172 ISLFMDILDFFGYKIASQKNYSPCSKDDKLEYAILLSKLYSKNDGFLIKLYSTSNAMISHIIPSI 236

  Fly   255 LI-ILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVITFFVCWFPFHLQR 318
            |. |:.:..:....:::.::||..:..:|.:.|           :::....|.|.:...|..:..
Worm   237 LFPIVTFFLVNVLRKAKKSRKLVSKTDSNTKST-----------KIIIYTAIIFLIVELPLGINL 290

  Fly   319 LIFLYAKN---MDNYLDINEALFSIAGFAYYVSCTVNPI----VYSVMSRRYRVAFRELL-CG 373
            .|..:..|   :...||..||||       |:..|.|.|    |..|:|.:||....::: ||
Worm   291 AIIWFFNNSVGIKLILDQFEALF-------YMLLTANTISHFFVCFVLSSQYRATLIDVVSCG 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	68/329 (21%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	61/309 (20%)
srw-130	NP_503993.3	7TM_GPCR_Srw	41..346	CDD:370978	70/353 (20%)
		TM helix 2	71..96	CDD:341315	5/25 (20%)
		TM helix 3	116..146	CDD:341315	9/33 (27%)
		TM helix 4	160..180	CDD:341315	8/31 (26%)
		TM helix 5	219..244	CDD:341315	8/24 (33%)
		TM helix 6	263..293	CDD:341315	5/40 (13%)
		TM helix 7	307..332	CDD:341315	11/31 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910