DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-60

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001364794.1	Gene:	srw-60 / 188409	WormBaseID:	WBGene00005807	Length:	382	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	91/443 - (20%)
Similarity:	157/443 - (35%)	Gaps:	124/443 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DTLFATSVSSDPSHGFGEEDYACGTFNCSPKEFVAFVLGPQTLPLYKAVLITIIFGGIF-ITGVV 84
            |..|......|.||   .|:....||:    |.:|           |.|.....|..:| :.|::
Worm     4 DWTFTEYYYDDMSH---PENARLRTFS----EIIA-----------KIVTFLKPFQCLFALIGLI 50

  Fly    85 GNLLVCIVIIRHSAMHTATNYYL-FSLAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCK----- 143
            .|:....:|.|.| |.|.:.|.| ..:.:||:.       |...:.::.:.|.|...||.
Worm    51 MNMFHLAIITRKS-MRTNSVYVLMIGITISDMF-------TMFMVVYNNFNDFFKFVFCSFPDPY 107

  Fly   144 -------IRAFISEACTYVSVFTIVAFSMERFLAICHPLH------------LYAMVGFKRAIRI 189
                   |.|.|.|....||.:.....::.|:|.|.:.:.            |...:|......|
Worm   108 WKVLLELILAAIQEIVRRVSTWLAFFMALFRWLIIKNTMSGSLGFLSKSSFALKTNIGVLILSTI 172

  Fly   190 ITAL-WIVSFISAIPFGLLSDIQYL--NYPLDHSR--------------IEESAFCSMS-PKIVN 236
            ||:| :....:..:.|.::|...:|  ||.:.|:.              :||.||.|.. ||::
Worm   173 ITSLTYSQKEVKDVGFEVISTCWFLEKNYKIAHTYSVGRSEFMDKNLNFVEEYAFMSDGIPKMI- 236

  Fly   237 EIPVFEVSFCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQ-MRKKTVIRML 300
                      ..|.:|::.|.|:     .::|         |...:.:...||: ::....|||
Worm   237 ----------AAFFLPILAIALV-----RRLR---------QAAESRKHLSNSKPLQTDKSIRM- 276

  Fly   301 AAVVITFFVCWFPFHLQRL-IFLYAKNMDNYLDINEALFSIAGFAYYVSCTVNPIVYSV------ 358
                :||...:..|....: ||.:.::.  ||..:....|:....   ...:|.::.:|
Worm   277 ----VTFMTLFSVFAEGPMGIFSFIRSF--YLRFSSIEASVESLD---KMLINLVIVNVIAHCFI 332

  Fly   359 ---MSRRYRVAFRELLCGKAVGAYYNSGFARDHSSFRESSAYDRVH---SVHV 405
               ||.:||....:|...|.:..:     .:|..|....:.....|   :|||
Worm   333 SMQMSSQYRDIATQLFLRKVIRRW-----KKDRVSVVPQAEMSLTHGPTNVHV 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	69/342 (20%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	63/315 (20%)
srw-60	NP_001364794.1	7TM_GPCR_Srw	40..351	CDD:402097	72/353 (20%)
		TM helix 2	69..94	CDD:410628	5/31 (16%)
		TM helix 3	113..143	CDD:410628	8/29 (28%)
		TM helix 4	157..177	CDD:410628	5/19 (26%)
		TM helix 5	223..247	CDD:410628	9/34 (26%)
		TM helix 6	268..298	CDD:410628	8/34 (24%)
		TM helix 7	311..337	CDD:410628	2/28 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910