DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-19

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_506785.2	Gene:	srw-19 / 188397	WormBaseID:	WBGene00005766	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	352	Identity:	76/352 - (21%)
Similarity:	136/352 - (38%)	Gaps:	72/352 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLL-YLLFGLPTEVFL 128
            |:..:.:.:.|..:||     |:|..||:.:......|....:..:.::|:| |||......:..
Worm    32 LFADINVCLQFFTVFI-----NILHLIVLFQKELRTGAIYILMIGICIADILGYLLDFYNVMIER 91

  Fly   129 YWHQYPDLFGMPFCKIRAFISEACTYVSV------FTIVAFSMERFLAICHPLHLYAMVGF---- 183
            .|.::...:....|     :.:..|||.|      |..:|..:..:||:...|.....|.|
Worm    92 TWIRWISFYSNIDC-----LRKDLTYVDVVDFIYIFVFMARPVAVWLAMLMALIRTLSVFFPMSN 151

  Fly   184 --------KRAIRIIT------ALWIVSFISAIPFGLLSDI---QYLNYP--LDHSRIEESAFCS 229
                    |.||.:|.      .:|......|:......|:   ...||.  |:|:.........
Worm   152 WIQKLSKPKNAIFMIVVVFTFWTIWHSCQFFAMTLRRYRDVLDKSCYNYEEHLNHTNSVLVVSVY 216

  Fly   230 MSPKIVN--EIPVFEVSFCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMR 292
            :|...||  ::..: :.|.:..:.|::.:.||       |:.||.:|   ::...|:...|.:..
Worm   217 VSNIYVNRKQLETY-LQFILTILYPILTVSLL-------IQLRTIKK---KRNNMNKNALNDRSD 270

  Fly   293 KKTVIRMLAAVVITFFVC--WFP----FHLQRLIFLYAKNMDNYLDINE-ALFSIAGFAYYVSC- 349
            ..|   .|..|:..||:.  ..|    |.|:|:    |:...|...:.| |||..|...:.::.
Worm   271 NTT---KLILVMTIFFMTSEGLPGVVSFILERI----ARASTNTGTMEEVALFLGAAQHFLINIR 328

  Fly   350 TVNPIVYS----VMSRRYRVAFRELLC 372
            |:|.|.::    .||.:||...:.:||
Worm   329 TLNGISHAFICFAMSSQYRDTVKRMLC 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	72/332 (22%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	66/310 (21%)
srw-19	NP_506785.2	7TM_GPCR_Srw	35..357	CDD:370978	75/349 (21%)
		TM helix 2	65..90	CDD:341315	5/24 (21%)
		TM helix 3	116..146	CDD:341315	5/29 (17%)
		TM helix 4	160..180	CDD:341315	5/19 (26%)
		TM helix 5	221..245	CDD:341315	4/24 (17%)
		TM helix 6	267..297	CDD:341315	7/32 (22%)
		TM helix 7	315..343	CDD:341315	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910