DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-22

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_506780.2	Gene:	srw-22 / 188392	WormBaseID:	WBGene00005769	Length:	350	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	69/359 - (19%)
Similarity:	127/359 - (35%)	Gaps:	104/359 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIR 145
            :.::.|||..:|:.|.:....|....:..:.:||.:..:..:            :.|......|.
Worm    15 SNILVNLLHLMVLTRKNPRCNAVFVLMIIICLSDNIQFILSI------------NKFSRQESWIT 67

  Fly   146 AFI------------------SEAC-TYV-------SVFTIVAFSMERFLAICHPLH-LYAMVG- 182
            :||                  :|.| |::       |.:..:..::.|.|::..|:. ..:.:|
Worm    68 SFIKDQRNTKCVKKQLVVLNFTEQCFTFIVGVFRRCSAWIALVMALIRMLSVIFPMSATISKMGK 132

  Fly   183 -----FKRAIRIITAL----WIVSFISAIPFGLLSDIQYLN-------------YPLDHSRIEES 225
                 |..:|.::..:    |...|:.   ...|.||...|             |.|   .:::|
Worm   133 PKGAIFMSSIVLLACVIIDAWAAVFLQ---IQWLPDIMVKNNKNCKPSKSANEKYVL---VVDQS 191

  Fly   226 AFCSMSPKIVNEIPVFEVSFCIF--FVIPMI-LIILLYGRMGAKIR--SRTNQKLGVQQGTNNRE 285
            .|     .:.|::...|:....|  .:.||: |.:||...|..|.|  |..|.|:         |
Worm   192 NF-----DLTNQLCFIEIIIRFFQTLLYPMLTLTLLLQLHMIKKKRIISSQNDKV---------E 242

  Fly   286 TRN--SQMRKKTVIRMLAAVVITF----FVCWFPFHL-QRLIFLYAKNMDNYLDINEALFSIAGF 343
            .||  :.:...||..|||..::.|    ..|.|...: .:...:||....|.:....||.|::
Worm   243 NRNLTNLIIFMTVSFMLAEGLVGFNGVVMYCTFVVEVWDKKWIIYAGAASNLIVNLRALNSLS-- 305

  Fly   344 AYYVSCTVNPIVYSVMSRRYRVAFRELLCGKAVG 377
                    :..|...||.:||...:.::....:|
Worm   306 --------HLFVCLFMSSQYRETVKNMMLNNKLG 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	68/350 (19%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	63/332 (19%)
srw-22	NP_506780.2	7tm_GPCRs	7..324	CDD:391938	68/350 (19%)
		TM helix 2	37..62	CDD:341315	3/36 (8%)
		TM helix 3	90..120	CDD:341315	6/29 (21%)
		TM helix 4	131..151	CDD:341315	3/19 (16%)
		TM helix 5	185..214	CDD:341315	6/36 (17%)
		TM helix 6	241..271	CDD:341315	9/38 (24%)
		TM helix 7	286..314	CDD:341315	7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910