DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and npr-20

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_495888.3	Gene:	npr-20 / 188226	WormBaseID:	WBGene00011578	Length:	410	Species:	Caenorhabditis elegans

Alignment Length:	395	Identity:	86/395 - (21%)
Similarity:	170/395 - (43%)	Gaps:	104/395 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 CSPKEFVAFVLGPQTLPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAV 112
            ||    |:|:..|     :..:.:.||:..:|:..:.||.|..||:..|..|.|.||::|.:||:
Worm    19 CS----VSFIDQP-----FVKIPVMIIYCLVFVVCLSGNFLTLIVMTSHPMMRTPTNFFLSNLAI 74

  Fly   113 SDLLYLLFGL---PTEVFLYWH-QYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICH 173
            :|||..:|.:   ...:..:.| .:|  .|...||:...::......|...:|..|:|:::|:.|
Worm    75 ADLLVAIFCILQNMIHIVGFDHGNWP--LGPVMCKLYLGLTNIMPCTSAGILVLVSLEKYIAVLH 137

  Fly   174 PLHLYAMVGFKRAIRIIT---------ALWIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCS 229
            ||         ..::::|         .:|::|.:...|:.|.:.    ||          .:..
Worm   138 PL---------SGLKLLTPEHRWVATMIVWVISILVNFPYFLYAQ----NY----------TYLG 179

  Fly   230 MSPKIVNEIPVF-EVSFCIFFVIPMILIILLYGRMGAKI-RSRTNQKLGVQQGTNN--------- 283
            :|......:|:: ..||.::::||:..::.:|.|:...: .|.:|::...|...:|
Worm   180 VSACFRGSMPIWNSFSFIVWYLIPLTALVFIYSRISHLLWTSDSNRQSSRQSHESNGSLERGNGY 244

  Fly   284 --------------------------------------RETRNSQMRKKTVIRMLAAVVITFFVC 310
                                                  :..::::.|:| |:|:|.|||::|.:.
Worm   245 ANTAQPGSSWQMKNGRIVVYKQESLLNVPKREKKVKEPKRPKDTEGRRK-VVRLLVAVVVSFALL 308

  Fly   311 WFPFHLQRLIFLYAKNM---DNYLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRYRVAFRELL- 371
            .||.|.:.|...:....   .|:..|.:.|..|   ..::|..:|||:|:.:|:|:|.|..:::
Worm   309 TFPHHARLLYTSFQTGTICNSNWTMIFQPLSYI---FLFISSAINPILYACLSKRFRNALSDVIH 370

  Fly   372 CGKAV 376
            |.|.|
Worm   371 CRKGV 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	76/354 (21%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	70/335 (21%)
npr-20	NP_495888.3	7tmA_Trissin_R	32..365	CDD:320140	77/361 (21%)
		TM helix 1	33..57	CDD:320140	8/23 (35%)
		TM helix 2	66..88	CDD:320140	8/21 (38%)
		TM helix 3	107..129	CDD:320140	3/21 (14%)
		TM helix 4	152..168	CDD:320140	2/15 (13%)
		TM helix 5	189..212	CDD:320140	5/22 (23%)
		TM helix 6	292..317	CDD:320140	11/25 (44%)
		TM helix 7	333..358	CDD:320140	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910