DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-134

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001309503.1	Gene:	srw-134 / 188103	WormBaseID:	WBGene00005881	Length:	348	Species:	Caenorhabditis elegans

Alignment Length:	312	Identity:	68/312 - (21%)
Similarity:	125/312 - (40%)	Gaps:	107/312 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 VIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVS 156
            :|.|:|......:|:|.|  |..||||:           :||               :..|:...
Worm    95 IISRYSKCFNTMSYHLVS--VDLLLYLV-----------NQY---------------ARRCSTWL 131

  Fly   157 VFTIVAFSMERFLAICHPLH-LYAMVGF-KRAIRII---TALWIVSFISAI-------------- 202
            :|::...   |.|.:.:|:: .|..:.. ..|:|:|   :|:.|:..||.:
Worm   132 LFSVAVI---RTLVLRNPMNPKYTELSKPSTALRVIFGVSAICIIFSISTVFENDVGVVGKQPSK 193

  Fly   203 --PFGLL------SDIQYLNYPLDHSRIEESAFCSMSPKIVNE-IPVFEVSFCIFFVIPMILIIL 258
              ..|:|      ||:..||   |...::.|.|   :..||:. ||      ||.|  |:|.::|
Worm   194 CSSHGVLMYAFTISDLFLLN---DGLLLKVSTF---TAAIVSHIIP------CIIF--PIITVLL 244

  Fly   259 LYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVITFFVCWFPFHLQRLIFLY 323
            :      |...:|:::.  :..|::::..:|  ||.|  :::....|.|.:..||..:...|..:
Worm   245 V------KELRKTDERR--KNSTSSKKITDS--RKTT--KLVFYNTILFLIAEFPLGVSMAITWF 297

  Fly   324 AKNMDNYLDI-------NEALFSIAGFAYYVSCTVNP----IVYSVMSRRYR 364
                  ::|:       |..|     |.:.:..|:|.    |:..:||.:||
Worm   298 ------FVDVPGLQLICNHCL-----FLFSMILTINTCSHFIISMLMSSQYR 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	68/312 (22%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	64/302 (21%)
srw-134	NP_001309503.1	7TM_GPCR_Srw	40..347	CDD:370978	68/312 (22%)
		TM helix 1	40..61	CDD:320109
		TM helix 2	70..92	CDD:320109
		TM helix 3	113..137	CDD:320109	9/49 (18%)
		TM helix 4	162..178	CDD:320109	5/15 (33%)
		TM helix 5	219..242	CDD:320109	11/33 (33%)
		TM helix 6	268..293	CDD:320109	7/26 (27%)
		TM helix 7	309..334	CDD:320109	6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910