DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-133

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_504144.2	Gene:	srw-133 / 188102	WormBaseID:	WBGene00005880	Length:	372	Species:	Caenorhabditis elegans

Alignment Length:	328	Identity:	70/328 - (21%)
Similarity:	134/328 - (40%)	Gaps:	60/328 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 NLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYWHQYPDLFG-----MPF---C 142
            |::..:|:.|.|...::.|..:.::|:.|:...|....|........|...|.     |.|   |
Worm    52 NVVHILVLTRKSMRTSSINVIMTAVAIFDICSYLLNFGTLAVRIISSYSKCFNESSYQMIFLNNC 116

  Fly   143 KIRAFISEACTYVSVFTIVAFSMERFLAICHPLH-LYA-MVGFKRAIRIITALWIVSFISAIPFG 205
            ..  ||:|.....|.:.:.:.::.|.|.|.:|:. .|| :.....|:|:|..:.|:..|.:|...
Worm   117 LF--FINEYARRCSTWLLFSVAVIRTLVIRNPMSPKYAKLSNSSTALRVIFGVSIICIIFSINTA 179

  Fly   206 LLSDIQYLNYP---------LDHSRIEESAFCSMSPKIVNEIPVFEVSF------CIFFVIPMIL 255
            |.::|:.::..         :.:..:....|. .:.:.:.:|..|..:.      ||.|.|..|:
Worm   180 LENEIEIIDRKPSECNSKGVISYGHVVSKLFW-QNDEFLLKISTFTTAIVSHIIPCILFPIITII 243

  Fly   256 IILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVITFFVCWFPFHLQRLI 320
            :|....|:..|.:|          .|::.:.::||.|.|.|...    .|.|.:..||......:
Worm   244 LINELRRIDVKRKS----------STSSNKAKDSQNRTKLVFYN----TILFLIAEFPLGFSMAV 294

  Fly   321 FLYAKNMDNYLDIN--EALFSIAGFAYYVSCTVNP----IVYSVMSRRYR-----VAFR-ELLCG 373
            ..:      ::|:.  :.:||.:.:.:.|..|:|.    ::..:||.:||     :.|. |||..
Worm   295 TWF------FVDVPGLQLIFSYSQYLFSVVLTINTSSHFVICMLMSSQYRNNAKILIFNVELLKN 353

  Fly   374 KAV 376
            |.|
Worm   354 KKV 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	68/324 (21%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	60/300 (20%)
srw-133	NP_504144.2	TM helix 1	37..61	CDD:320109	2/8 (25%)
		7TM_GPCR_Srw	40..346	CDD:370978	64/316 (20%)
		TM helix 2	70..92	CDD:320109	5/21 (24%)
		TM helix 3	115..137	CDD:320109	5/23 (22%)
		TM helix 4	162..178	CDD:320109	5/15 (33%)
		TM helix 5	219..242	CDD:320109	6/22 (27%)
		TM helix 6	268..293	CDD:320109	8/28 (29%)
		TM helix 7	309..334	CDD:320109	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910