DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-2

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_503766.3	Gene:	srw-2 / 188012	WormBaseID:	WBGene00005749	Length:	373	Species:	Caenorhabditis elegans

Alignment Length:	379	Identity:	64/379 - (16%)
Similarity:	131/379 - (34%)	Gaps:	123/379 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PKEFVAFVLGP----QTLPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSL 110
            |||.|.:|..|    :....:..|:..:.|..:.|     ||:...|:.|...  .|.:.|...:
Worm    20 PKEIVKYVEIPSWFDEVFLKFNYVIAILQFFAVAI-----NLIHLSVLTRKEL--RAISIYRIMI 77

  Fly   111 A------VSDLLYLLFGLP---------TEVFL---YWHQYPDLFGMPFCKIRAFISEACTYVSV 157
            .      :|::|..:...|         .|.::   |.....|.:|:|   :........:::::
Worm    78 VICILDIISEILSFISFSPFWIRETLEGQECYVTVTYRDALIDQYGVP---VLDMTQRGSSWLNL 139

  Fly   158 FTIVAFSMERFLAICHPLHLYAMVGFKRAIR--IITALWIVSFISAIPFGLLS---------DIQ 211
            |    .::.|.|||.:|:        ..||.  :|..::::  ||.|..|:.|         ..|
Worm   140 F----MALLRVLAITYPM--------SSAIEKPVIVPVFVL--ISLIFNGICSICVTWNFEVTQQ 190

  Fly   212 YLNYPLDHSRIEESAFCSMSPKIVNEIPV--FEVSFCIFFVI-----------PMILIILLYGRM 263
            |:::..|.:   ::...:.:.:.:..:||  .|:...:.|:.           |::.:||:
Worm   191 YMDFSCDGT---QNLLPANASRYIRTVPVGKKELHSTLVFIYGIIKALPSLVEPILAVILI---- 248

  Fly   264 GAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVI----------RMLAAVVITFFVCWFPFHLQR 318
                                .|.:.:..|:||::          :::..:.|:.|:...|.....
Worm   249 --------------------MELKRASQRRKTMLKSDGKGENTTKLILFMTISSFLLEVPNGFSH 293

  Fly   319 LIFLYAKNMDNYLDINEALFSIAGFAYYVSCTVNPIVYS--------VMSRRYR 364
            ..|.:.        ....|...|.:...|...:.|:..|        .||..||
Worm   294 FAFGFF--------TTSPLIKTASYLIMVFAEIFPVTNSSTHLFVCFFMSTLYR 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	55/340 (16%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	50/322 (16%)
srw-2	NP_503766.3	7TM_GPCR_Srw	42..348	CDD:370978	58/357 (16%)
		TM helix 1	42..65	CDD:341315	6/27 (22%)
		TM helix 2	72..97	CDD:341315	3/24 (13%)
		TM helix 3	120..150	CDD:341315	7/36 (19%)
		TM helix 4	158..176	CDD:341315	4/19 (21%)
		TM helix 5	211..246	CDD:341315	5/34 (15%)
		TM helix 6	266..296	CDD:341315	3/29 (10%)
		TM helix 7	309..335	CDD:341315	3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910