DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-7

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_504053.1	Gene:	srw-7 / 187706	WormBaseID:	WBGene00005754	Length:	381	Species:	Caenorhabditis elegans

Alignment Length:	450	Identity:	81/450 - (18%)
Similarity:	152/450 - (33%)	Gaps:	119/450 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NASFTNTPDTLFATSVSSDPSHGFGEEDYACGTFNCSPKEFVAFV-LGPQTLPLYKAVLITIIFG 76
            |.:.|.||...:         |.:.|..|....|.....::.::: ...:.|.:...|.:...|.
Worm     6 NKNPTTTPGEYY---------HTYEESFYWYFNFFEDDDDYYSWLDYVHEVLYILSRVYVVFSFI 61

  Fly    77 GIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPF 141
            ..||     |:....|:.|...........:.::.:.:.......:..| ||.|:        .|
Worm    62 QFFI-----NIFHMTVLTRRELRTNLVYQVMIAICIGETAQAFVTMFDE-FLTWN--------IF 112

  Fly   142 CKIRAFISEACTYVSVFTIV-------AFSMERFLAICHPLHLYAMVGFKRAIRIITAL------ 193
            .|:..:    |.|.....::       .|...||.|.   |.||  :...||..:|..:
Worm   113 YKVELW----CGYPYFHLVIRRLAISSQFLSRRFSAF---LGLY--IAAVRAFSVIFPMSAITHK 168

  Fly   194 -------WIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCSMS-PKIV------NEIPVFEVS 244
                   ::|..:.||.....|..|:|...::    :.:.:|:.: |..|      ||..|.:.:
Worm   169 ITKPNSGFMVMSVIAIASTAWSSFQFLQTSIE----KVTKYCTYNRPSYVPYLLLNNEKLVDKFN 229

  Fly   245 F---CIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVI- 305
            :   ||..|:..:.:.:....:....|::..:|        |..:.......|.|:.|.|.|.:
Worm   230 YADSCISLVVSTLYVFVALALVVELQRTKKRRK--------NLRSEKPNNTTKLVVVMAATVFVS 286

  Fly   306 -TFF--VCWFPFHL------QRLIFLYAKNMDNYLDINEALFSIAGFAYYVSCTVNPIVYSVMSR 361
             :|:  :.:..||.      |.||..:|..|       :.|...:..|:.|.|       ..||.
Worm   287 ESFYGLLRYIAFHTFAGYEEQPLIQQFADRM-------QLLVMASSIAHCVIC-------YCMSS 337

  Fly   362 RYRVAFRELLCGKAVGAYYNSGFARDHSSFRESSAYDRVHSVHVRASQHPNKFETDSSSA 421
            :||...::::           |..::..:         |..|.|..:.||....:..||:
Worm   338 QYRDTLKKMI-----------GVGKEDKT---------VKIVIVETTTHPTTVNSSKSSS 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	60/328 (18%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	56/310 (18%)
srw-7	NP_504053.1	TM helix 1	50..76	CDD:341315	6/30 (20%)
		7TM_GPCR_Srw	54..350	CDD:370978	65/355 (18%)
		TM helix 2	83..111	CDD:341315	4/36 (11%)
		TM helix 3	129..159	CDD:341315	9/34 (26%)
		TM helix 4	173..193	CDD:341315	4/19 (21%)
		TM helix 5	226..249	CDD:341315	3/22 (14%)
		TM helix 6	267..298	CDD:341315	6/30 (20%)
		TM helix 7	311..336	CDD:341315	6/38 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910