DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-115

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_503815.2	Gene:	srw-115 / 187325	WormBaseID:	WBGene00005862	Length:	367	Species:	Caenorhabditis elegans

Alignment Length:	352	Identity:	77/352 - (21%)
Similarity:	135/352 - (38%)	Gaps:	95/352 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 IFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLL----FGLPTEVFLYWHQYPD-LF 137
            :.|..::.||:...::.|.....::.|..:.::|:.|:|..|    ..|....::::..||. .:
Worm    45 VSIASILINLIHFFILTRKPMRTSSINILMAAIALFDILASLQQIELLLDRYSYIFFDCYPTYTY 109

  Fly   138 GMPFCK-----IRAFISEACTYVSVFTIVAF---------SMERFLAICHPLHLYAMVGFKRAIR 188
            |:...|     :|.:.....|::.||  :||         ...:|.|:|.|         |.:..
Worm   110 GLELTKVLLDVVRDYSRRCSTWLIVF--IAFIRTLIVRNPMSTKFEALCQP---------KASAI 163

  Fly   189 IITALWIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCSMSPKIVNEIPVFEVS--------- 244
            ||..:...||    |..:|..::|     ....||....|:..|.     .:|.||
Worm   164 IIAGICATSF----PVSVLKFLEY-----QFIEIEGLESCAKGPH-----HIFAVSDLFTANDGF 214

  Fly   245 ----FCIF--FV---IPMILI----ILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTV 296
                |.:|  ||   :|.||:    :||...:....:.||| .:.|.:..|:|
Worm   215 LAKYFYLFNSFVSDIVPCILLPIVTLLLVMDLWRAAKKRTN-LISVSKNHNSR------------ 266

  Fly   297 IRMLAAVVITFFVCWFPFHLQR-LIFLYAKNMDNYLDINEALFSIAGFAYYVSCTVNP----IVY 356
            ..::..|.|.||:..||:.|.. .:::|    ::.|.:...:...| |.:.:..|:|.    .|.
Worm   267 TGLVFCVTIMFFIVEFPYGLSMGFVWMY----NDVLGLQHMMSRFA-FMFAMLITLNTCTHLFVC 326

  Fly   357 SVMSRRYR-VAFRELLCGKAVGAYYNS 382
            .::|..|| .|.....||     |.||
Worm   327 LIISSHYRSTAIYVFSCG-----YINS 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	72/335 (21%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	66/316 (21%)
srw-115	NP_503815.2	TM helix 1	41..62	CDD:320109	3/16 (19%)
		7TM_GPCR_Srw	45..344	CDD:370978	72/341 (21%)
		TM helix 2	71..93	CDD:320109	5/21 (24%)
		TM helix 3	116..138	CDD:320109	4/23 (17%)
		TM helix 4	163..179	CDD:320109	5/19 (26%)
		TM helix 5	217..240	CDD:320109	7/22 (32%)
		TM helix 6	267..289	CDD:320109	7/21 (33%)
		TM helix 7	305..330	CDD:320109	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910