DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-32

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_507436.1	Gene:	srw-32 / 186949	WormBaseID:	WBGene00005779	Length:	367	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	71/380 - (18%)
Similarity:	136/380 - (35%)	Gaps:	83/380 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GTFN--CSPKEFVAFVLGPQTLPLYKAVL----ITIIFGGIFITGVVG---NLLVCIVIIRHSAM 99
            |.||  .....|||.::|.....::..:|    :..:...:|:||:..   ...:||:||    .
Worm    28 GYFNYYSDHVHFVALIVGTVLGVIHLTILTRKCMRALRINVFLTGIAAAEITRTICIIII----F 88

  Fly   100 HTATNYYLFSLAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFS 164
            ....|....|..|||.               |.......:....:.|..:.....:||:..||.:
Worm    89 VPFFNLRYLSDKVSDC---------------HDPESTVAVFSYNVSASFTRITEKISVWLAVAIA 138

  Fly   165 MERFLAICHPLH--LYAMVGFKRAIRIITALWIVSFISAIPFGLLSDIQYLNY-PLDHSRIEE-- 224
            :.|.|.:.:.::  :......|..::|:..:.::    .:|||.      .|| .|..:.:.|
Worm   139 VIRTLVMRYLVNGRINCWTDAKYGLKIVLLITLL----ILPFGA------SNYSKLSSTSVREWT 193

  Fly   225 -----SAFCSMSPKI---------VNEIPVFEVSFCI---------FFVIPMILIILLYGRMGAK 266
                 ..|...|.||         .....||:::..|         ..::|:..|.|:.....|:
Worm   194 PFTNCITFSGNSTKIKFDFHSTELFGSTDVFKIALLIEGIFLEFTPSIILPITTISLIMDLRKAR 258

  Fly   267 IRSRTNQKLGVQQGTNNRETRNSQMRKKTV--IRMLAAVVITFFVCWFPFHLQRLIFLYAKNMDN 329
                          .|:..|::|.....||  |:::|.|.|||.....|.....::.::...|..
Worm   259 --------------KNSLFTKSSLSSSDTVRSIKLVAFVTITFLFTTTPLGFMYIVGIFIVTMPG 309

  Fly   330 YLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRYRVAFRELLCGKAVGAYYNSGF 384
            .:.:......:..|...:|..|:.::..:||.:||....::. ||....:.::.|
Worm   310 LIMLVTKFAWVLTFLTTISGIVHILICYLMSMQYRSTAHKMF-GKNRKIFISTSF 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	57/321 (18%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	53/303 (17%)
srw-32	NP_507436.1	7TM_GPCR_Srw	36..354	CDD:370978	66/361 (18%)
		TM helix 2	66..91	CDD:341315	7/28 (25%)
		TM helix 3	116..146	CDD:341315	7/29 (24%)
		TM helix 4	166..191	CDD:341315	6/34 (18%)
		TM helix 5	224..249	CDD:341315	3/24 (13%)
		TM helix 6	271..302	CDD:341315	9/30 (30%)
		TM helix 7	315..340	CDD:341315	3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910