DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-122

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_503802.2	Gene:	srw-122 / 186790	WormBaseID:	WBGene00005869	Length:	372	Species:	Caenorhabditis elegans

Alignment Length:	336	Identity:	82/336 - (24%)
Similarity:	137/336 - (40%)	Gaps:	73/336 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 IFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYWHQYPDLF----- 137
            |.|:.::.||:...::.|.....::.|..:.::|..|:...|  ||.||.  :.:|.|:|
Worm    45 ISISSILINLVHFFILTRKPMRTSSINILMAAVAFFDIFTSL--LPIEVL--FERYKDIFFECLS 105

  Fly   138 ----GMPFCKIRAFI----SEACTYVSVFTIVAFSMERFLAICHPL-HLYAMVGF-KRAIRIITA 192
                |:...|....:    |..|:...:| .:||.  |.|.|.:|| ..|..:|. |.:|.:||.
Worm   106 LDTYGLVLTKALLTVVKDYSRRCSTWLIF-FIAFI--RTLIIQNPLSSKYEALGKPKASIIVITG 167

  Fly   193 LWIVSF-ISAIPFGLLSDIQYLNYPLDHSRIEESAFCSMSPK---IVNEIP--------VFEVSF 245
            :.:.:| ||...|            |::..||.....|.:|.   |||.:.        |....|
Worm   168 ICVATFPISMFKF------------LENEFIESLPRDSCAPNKTYIVNVLSELFMKNDGVIMEYF 220

  Fly   246 CIF-----FVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVI 305
            .:|     .::|.||::::...:...:...:.:|..:....|||.:|.     ||  .::..|.|
Worm   221 YLFNSSISDIVPCILLLIVTCLLVWNLFKTSKKKAKMSSVPNNRNSRG-----KT--GLVLCVAI 278

  Fly   306 TFFVCWFPFHL---QRLIFLYAKNMDNYLDINEALFSIAGFAYYVSCTVNP----IVYSVMSRRY 363
            .||:..||:.|   ...||:.|....|.|  |:     .|:.:.:..|:|.    .|...||.:|
Worm   279 MFFIVQFPYGLSVGSAGIFILAPGAHNML--NQ-----FGYIFSMLITLNTCTHLFVCLFMSSQY 336

  Fly   364 R-VAFRELLCG 373
            | .......||
Worm   337 RSTTIHVFTCG 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	80/329 (24%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	73/309 (24%)
srw-122	NP_503802.2	7TM_GPCR_Srw	45..347	CDD:370978	80/334 (24%)
		TM helix 2	71..93	CDD:320109	8/25 (32%)
		TM helix 3	116..138	CDD:320109	3/22 (14%)
		TM helix 4	163..179	CDD:320109	5/15 (33%)
		TM helix 5	218..241	CDD:320109	5/22 (23%)
		TM helix 6	270..292	CDD:320109	8/23 (35%)
		TM helix 7	308..333	CDD:320109	5/29 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910