DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-87

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_507129.1	Gene:	srw-87 / 186467	WormBaseID:	WBGene00005834	Length:	361	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	66/413 - (15%)
Similarity:	148/413 - (35%)	Gaps:	113/413 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PQTLPLYKAVLITIIFGGIFITGVVGNLLVC--IVIIRHSAMH-TATNYYLFSLAVSDLLYLLFG 121
            |.:|.|:.:.|:..:....:|...:..::.|  |.|:....|. ::.|..|..:|::|:.:.|..
Worm     4 PASLQLFFSNLVATVGAYEYIFATIELMINCFHIFILSRPRMRISSMNSILLGIALADIFFPLIA 68

  Fly   122 LPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLH---------L 177
            :..:..::      :||          |:.||...  :::..|::.||   :.|.         |
Worm    69 IKKKARVW------IFG----------SDECTEPQ--SLLETSLDWFL---YTLRDDFRRCSTWL 112

  Fly   178 YAMVGFKRAIRIITAL-------------WIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAF-- 227
            ..|:...|.:.:...:             |.::||........|...|..|.:    :....|
Worm   113 GLMLAGVRTVAVRNVMNQNYNHISQPAFGWKINFIVLGVSTFFSIFYYFRYEV----VNNGTFWT 173

  Fly   228 ----CSMSPK-------IVNEIPVFEVSFCIFFVIPMILI----------------ILLYGRMGA 265
                |:..|.       ::.|...::.:..:|..|.::::                |:|...:..
Worm   174 PPATCAQYPAGFRVPNFVLQEREFYKAANGLFRTINLLVVGVLAKFLPCILFPTLTIILTKELKK 238

  Fly   266 KIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVITFFVCWFP----FHLQRLIFLYAKN 326
            .:|:|...:   :.|...:       :|:...|.:..:.::|.:..||    |.::....:|::.
Worm   239 AVRAREEAR---KDGAVGK-------KKEVATRFVIYMTVSFVIIEFPIGICFCIEAASGIYSQG 293

  Fly   327 MDNYLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRYRVAFRELLCGKAVGAYYNSGFARDHSSF 391
                 ....::..:....|.|....:.::...||.:||...:::             |:|..|
Worm   294 -----SAASSIIQLLNMVYVVLTLSHFLICFSMSSQYRKTVKQI-------------FSRGPS-- 338

  Fly   392 RESSAYDRVHSVHVRASQHPNKF 414
            .::.|...:..||.|.||..:.|
Worm   339 LQNKAKSVISVVHNRKSQPSSSF 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	51/346 (15%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	47/328 (14%)
srw-87	NP_507129.1	7TM_GPCR_Srw	21..336	CDD:370978	53/367 (14%)
		TM helix 2	51..73	CDD:320109	5/21 (24%)
		TM helix 3	96..118	CDD:320109	5/24 (21%)
		TM helix 4	143..159	CDD:320109	3/15 (20%)
		TM helix 5	200..230	CDD:320109	2/29 (7%)
		TM helix 6	259..282	CDD:320109	4/22 (18%)
		TM helix 7	297..322	CDD:320109	2/24 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910