DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and ntsr2

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_017949971.1	Gene:	ntsr2 / 101730337	XenbaseID:	XB-GENE-22068810	Length:	430	Species:	Xenopus tropicalis

Alignment Length:	371	Identity:	100/371 - (26%)
Similarity:	169/371 - (45%)	Gaps:	73/371 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VLITIIFGGIFITGVVGNLLVCIVII----RHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLY 129
            |.||:.:..||:.|.:||:|...:::    ||....| .:|:|.|:|:||:|.||..:|.|::.:
Frog    37 VFITVFYILIFLVGTIGNVLTIRLVLKKHNRHKLQGT-VHYHLVSMALSDILILLISIPIELYNF 100

  Fly   130 -WHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLHLYAMVGFKRAIRIITAL 193
             |..||.:||...|:...|:.:.|:|.:|..|.:.|.||:||||||:....::...|..:|::.:
Frog   101 IWVHYPWIFGDAVCRSYYFLRDICSYATVLNITSLSCERYLAICHPMTAKRIMSKMRTKKILSVI 165

  Fly   194 WIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFC-----SMSPKIVNEIPVFEVSFCIFFVIPM 253
            |..|.:.|:|...:..::|.|...:......|..|     :.:.|:..::.||     :.|::|:
Frog   166 WFSSVVFAMPMAFIMGVKYENTTPEGEEDPSSLICTNLVSTATLKVFIQVNVF-----VSFLLPL 225

  Fly   254 ILIIL-----------LYGRMGAKIRSRTN---------------------QKLGVQQGTNNRET 286
            .||..           |..|....:.|.:.                     :||.| .|..::.:
Frog   226 ALISCLNCVTVNQLESLRSRYFLSLHSSSKAPQASYRAHVSLKPVSSSPAVKKLSV-AGATSKSS 289

  Fly   287 RNSQMRKKTV------IRMLAAVVITFFVCWFPFHLQRLIFLYAKNMDNY-----LDINEALFSI 340
            .........:      |.||.|:||.:.|||.|:|.:||:|.|..  |:|     .......:.:
Frog   290 LTVSCEPNRIQPIQHSIYMLRAIVIAYVVCWLPYHARRLMFCYIP--DDYWTGFLYTFYHYFYML 352

  Fly   341 AGFAYYVSCTVNPIVYSVMSRRYRVAFRELLCGKAVGAYYNSGFAR 386
            ....:|||..||||:|:::|..:|..|.|.|           ||:|
Frog   353 TNTLFYVSSAVNPILYNMVSSSFRELFLETL-----------GFSR 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	91/341 (27%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	85/323 (26%)
ntsr2	XP_017949971.1	7tm_GPCRs	36..379	CDD:391938	94/350 (27%)
		TM helix 1	38..63	CDD:341315	8/24 (33%)
		TM helix 2	75..97	CDD:341315	10/21 (48%)
		TM helix 3	115..137	CDD:341315	5/21 (24%)
		TM helix 4	160..176	CDD:341315	4/15 (27%)
		TM helix 5	210..233	CDD:341315	7/27 (26%)
		TM helix 6	303..328	CDD:341315	11/24 (46%)
		TM helix 7	347..372	CDD:341315	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020