DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and nmur1

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_002937396.1	Gene:	nmur1 / 100498264	XenbaseID:	XB-GENE-940641	Length:	430	Species:	Xenopus tropicalis

Alignment Length:	421	Identity:	128/421 - (30%)
Similarity:	215/421 - (51%)	Gaps:	58/421 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NCSPKEFVAFVLGPQTLPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLA 111
            |.:.:|.:...|||:....:..:.|..:|  ||..|.|||.|.|||||:|..|.|.|||||.|||
Frog    47 NMTMEELLFKYLGPRRSTYFTPICIIYLF--IFAVGAVGNTLTCIVIIKHKIMRTPTNYYLLSLA 109

  Fly   112 VSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLH 176
            :||||.||.|:|.|::..|..||.:||...|..:..:.|...:.|:..:.|.|:||::|:.|||.
Frog   110 ISDLLVLLLGMPLELYELWSNYPFVFGQSGCSFKTLLFETVCFASILNVTALSVERYIAVVHPLR 174

  Fly   177 LYAMVGFKRAIRIITALWIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCS-MSPKIVNEIPV 240
            ...:|....|.|:|.::|::|.:.:||...|:.|.:|.. |....:..||.|: :.|:.:..: :
Frog   175 AKYVVTRNHAKRVIFSVWVISILCSIPNTSLNGILHLRV-LGIGIVPGSATCTVVRPRWIYNL-I 237

  Fly   241 FEVSFCIFFVIPMILIILLYGRMGAKIRSR-----TNQKLGVQ-QGTNNRETRNSQMRKKTVIRM 299
            .:::...||.:||..|.:||..:|.:::..     ...|.|.: .|..|...:..::|::.|.:|
Frog   238 IQITTIFFFFLPMGTISVLYLLIGLQLKKEKMLQVLETKSGKEGDGYQNVRLQQEKIRRRQVTKM 302

  Fly   300 LAAVVITFFVCWFPFHLQRLIFLYAKNMDNYLDINEALFS----IAGFAYYVSCTVNPIVYSVMS 360
            |..:|:.|.:||.|||.:||::.:   ::::.::...:||    |:|..:|:|..||||:|:::|
Frog   303 LFILVVVFGICWAPFHTERLMWSF---INDWTEVMHQIFSFVHVISGVLFYLSSVVNPILYNLLS 364

  Fly   361 RRYRVAFRELLCGKAVGAYYNSGFARDHSSFRESSAYDRVHSVHVRASQHPNKFETDSSSANRVL 425
            .|:|..|:|::|                        :.|...:..|.|         |.|..||.
Frog   365 TRFREMFKEVMC------------------------HGRTKRLGSRRS---------SPSVTRVT 396

  Fly   426 IKKTYSLPLPKNADSTVLSTTDI---VIVLE 453
            .:.|....:|.|.    |..:|:   |:.||
Frog   397 TRSTVCENVPGNG----LRFSDVDEFVVYLE 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	102/299 (34%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	95/281 (34%)
nmur1	XP_002937396.1	7tmA_NMU-R1	67..371	CDD:320480	105/310 (34%)
		TM helix 1	67..94	CDD:320480	14/28 (50%)
		TM helix 2	101..127	CDD:320480	17/25 (68%)
		TM helix 3	140..170	CDD:320480	8/29 (28%)
		TM helix 4	182..204	CDD:320480	7/21 (33%)
		TM helix 5	234..263	CDD:320480	8/29 (28%)
		TM helix 6	294..324	CDD:320480	13/29 (45%)
		TM helix 7	339..364	CDD:320480	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	1	1.000	-	-		FOG0001494
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010