DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and nmur2

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_002940961.1	Gene:	nmur2 / 100498226	XenbaseID:	XB-GENE-6046084	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	341	Identity:	123/341 - (36%)
Similarity:	196/341 - (57%)	Gaps:	44/341 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SPKEFVAFVLGPQ----TLPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFS 109
            |.:|::|::.||:    :||:      |:::..||:.||:||.|||:||::|..|.|.|||||||
Frog    27 STEEYLAYLCGPKRSRLSLPM------TLVYATIFLIGVIGNTLVCLVILKHHNMRTPTNYYLFS 85

  Fly   110 LAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHP 174
            |||||||.||.|:|.||:..|..||.|||...|..:..:.|...:.|:.::...|:||::||.||
Frog    86 LAVSDLLVLLLGMPLEVYEMWSNYPFLFGAWGCYFKTVLFETVCFASILSVTTVSVERYVAIIHP 150

  Fly   175 LHLYAMVGFKRAIRIITALWIVSFISAIP----FGLLSDIQYLNYPLDHSRIEESAFCSMSPKIV 235
            ..........||::|:..|||.|.:.:||    .|:|  :||  :| :.|.|.:||.|::...:.
Frog   151 FQAKLKSTRSRALKILVTLWIFSILFSIPNTSTHGIL--LQY--FP-NGSLIPDSATCTVVQPLW 210

  Fly   236 NEIPVFEVSFCIFFVIPMILIILLYGRMGAKIR---SRTNQKLGVQQGTNNRETRNSQMRKKTVI 297
            ....:.:|:..:|:::||.:|.:||..||.|:|   |....|:.|.....:|         |::.
Frog   211 IYNCIIQVTSLLFYILPMGVISVLYCLMGIKLRGDHSLEADKMSVNVQRPSR---------KSIT 266

  Fly   298 RMLAAVVITFFVCWFPFHLQRLIFLYAKNMDNYLDINEALFS-------IAGFAYYVSCTVNPIV 355
            :||..:|:.|.:||.|||:.||.|.:.      ||..|.|.:       ::|..:|:|..|||::
Frog   267 KMLFVLVMVFGICWAPFHVDRLFFSFV------LDWTEPLANAFNLTHVVSGVFFYLSSAVNPLI 325

  Fly   356 YSVMSRRYRVAFRELL 371
            |:::|||:|.||:.:|
Frog   326 YNLLSRRFRSAFQNVL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	111/301 (37%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	103/284 (36%)
nmur2	XP_002940961.1	7tmA_NMU-R2	45..337	CDD:320479	115/317 (36%)
		TM helix 1	45..72	CDD:320479	14/32 (44%)
		TM helix 2	79..105	CDD:320479	20/25 (80%)
		TM helix 3	118..148	CDD:320479	7/29 (24%)
		TM helix 4	160..182	CDD:320479	9/21 (43%)
		TM helix 5	212..241	CDD:320479	9/28 (32%)
		TM helix 6	260..290	CDD:320479	13/38 (34%)
		TM helix 7	305..330	CDD:320479	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H49618
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3581
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	1	1.000	-	-		FOG0001494
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.100