DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn10 and PSMD4

DIOPT Version :9

Sequence 1:	NP_001262168.1	Gene:	Rpn10 / 40388	FlyBaseID:	FBgn0015283	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001317621.1	Gene:	PSMD4 / 5710	HGNCID:	9561	Length:	380	Species:	Homo sapiens

Alignment Length:	405	Identity:	236/405 - (58%)
Similarity:	288/405 - (71%)	Gaps:	34/405 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLESTMICFDNSDFQRNGDYFPTRLIVQRDGINLVCLTKLRSNPENNVGLMTLSNTVEVLATLT 65
            |||||||:|.|||::.||||:.||||..|:|.:|:||.:|.||||||||||:||:|..|||.|||
Human     1 MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLT 65

  Fly    66 SDAGRIFSKMHLVQPKGEINLLTGIRIAHLVLKHRQGKNHKMRIVVFVGSPINHEEGDLVKQAKR 130
            .|.|||.||:|.|||||:|...||||:|||.|||||||||||||:.|||||:...|.||||.|||
Human    66 PDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKR 130

  Fly   131 LKKEKVNVDIVSFGDHGNNNEILTAFINALNGKDGTGSHLVSVPRGSVLSDALLSSPIIQGEDGM 195
            ||||||||||::||:...|.|.||||:|.||||||||||||:||.|..|:|||:||||:.||
Human   131 LKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGE--- 192

  Fly   196 GGA--GLGGNVFEFGVDPNEDPELALALRVSMEEQRQRQESEQRRANPDGAPPTGGDAGGGGGVS 258
            |||  |||.:.|||||||:.||||||||||||||||||||.|.|||    |..:..:||
Human   193 GGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRA----AAASAAEAG------ 247

  Fly   259 GSGPGNEESAGAENEANTEEAMLQRALALSTETPEDNLPDFANMTEEEQIAFAMQMSMQDAPDDS 323
                  ..:.|.|.|.::::|:|:..:: ..|.....|||.::||||||||:|||||:|.|.
Human   248 ------IATTGTEGERDSDDALLKMTIS-QQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAE--- 302

  Fly   324 VTQQAKRPKTDEANA-----PMDVDEDYSEVIGDPAFLQSVLENLPGVDPQSEAVRDAVGSL--N 381
             ..||:....|.::|     |...::|| :|:.||.||||||||||||||.:||:|:|:|||  .
Human   303 -FGQAESADIDASSAMDTSEPAKEEDDY-DVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQ 365

  Fly   382 KDKDKKSDGKDSQKK 396
            ..||.|.|.|:..||
Human   366 ATKDGKKDKKEEDKK 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn10	NP_001262168.1	VWA_26S_proteasome_subunit	1..187	CDD:238729	129/185 (70%)
PSMD4	NP_001317621.1	VWA_26S_proteasome_subunit	1..187	CDD:238729	129/185 (70%)
		Essential for ubiquitin-binding	216..220		3/3 (100%)
		Essential for ubiquitin-binding	290..294		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..330		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..380		19/35 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146912
Domainoid	1	1.000	163	1.000	Domainoid score	I3972
eggNOG	1	0.900	-	-		E1_COG5148
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55691
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1812
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S715
OMA	1	1.010	-	-		QHG54175
OrthoDB	1	1.010	-	-		D1244685at2759
OrthoFinder	1	1.000	-	-		FOG0004243
OrthoInspector	1	1.000	-	-		otm42101
orthoMCL	1	0.900	-	-		OOG6_102002
Panther	1	1.100	-	-	LDO	PTHR10223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1199
SonicParanoid	1	1.000	-	-		X2982
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750