DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7611 and GID7

DIOPT Version :9

Sequence 1:	NP_001163489.1	Gene:	CG7611 / 40386	FlyBaseID:	FBgn0037094	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_009891.1	Gene:	GID7 / 850318	SGDID:	S000000544	Length:	745	Species:	Saccharomyces cerevisiae

Alignment Length:	784	Identity:	167/784 - (21%)
Similarity:	279/784 - (35%)	Gaps:	298/784 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 FIVNNNGSSSRIVDGENNRENTSCSGVQ-LDKSNQEIIRLIGQYLHDVGLDKSVQTLMLESGCY- 127
            :::||           :..|..|.|.|. .||  :::.:|:...|.::|.|.:...|:||||.|
Yeast     9 YVLNN-----------DTEETASPSSVGCFDK--KQLTKLLIHTLKELGYDSAANQLLLESGGYQ 60

  Fly   128 ------------------------------LEH------------------PSATKFREHVLMGD 144
                                          |.|                  |:.|...:|:|:
Yeast    61 NESNHIQTFFKLIKTGQFHLINWQIVCSLPLAHSSPLRSEWLQRLLIPTPTPATTSLFDHMLL-- 123

  Fly   145 WSKADSDLKDLEPLI--------DNGKLATI---TEMKFILLEQKYLE----------HLDDGNP 188
                  .|:.|:.|:        .:.::||:   .|:..::..|.:||          |......
Yeast   124 ------QLQYLQQLMSSVNSSTCSDAEIATLRNYVEIMILVNRQIFLEFFHPVTNSASHKGPHTA 182

  Fly   189 LDALHVLRSELTPL----------------QHNI----TRVHQLSSYMMCSTNQDLYQRAKWEGK 233
            |..|: ||..|...                :.||    |.:.:||:|:   ||..|..:..
Yeast   183 LPVLY-LRKILKNFIEIWDSLLVSNDQFLNEENIFNPETTLRELSTYL---TNPKLTAQLN---- 239

  Fly   234 GILSRALVMERLQTFMPPSVMMSPRRLRTLLQQAVEL-QSQHC-----PCHDMAWETNLETVSLL 292
              |.|..:::.:..::.|:.::...||..||:||::. |||..     |..|.::.:....::||
Yeast   240 --LERDHLIDAISKYIDPNELVPKGRLLHLLKQAIKYQQSQDIFNIIDPDDDASFSSPPHRINLL 302

  Fly   293 TD---HCCTTDGFPMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDST----VIIWDVDP----Y 346
            .|   |..|......:|||   |..||:||..|||:|..||:.:.:|:    :.::||:.    |
Yeast   303 QDNFSHDLTVTFQEWKTIQ---DTTDEIWFLTFSPNGKYLASATSESSRGYFITVYDVEQDFKIY 364

  Fly   347 KLTLKHRRVLDGQAQLSVSFVSWSPDSKLILV-------------------GGTEDSHELY---- 388
            |..:        ....||.::.:||||:.::.                   ....||..||
Yeast   365 KTCV--------SLSQSVLYLMFSPDSRYLVACPFSEDVTIYDMNATSLPDASATDSFLLYPSTR 421

  Fly   389 -------------------------------------IWNVD----------------DGKLVVK 400
                                                 :|..|                |.:.:|
Yeast   422 LSPMDSFKLDTTTYPDDTESSASSSSRPANANSNQSRVWCCDAFHTAERAGWMVVGSPDREAIV- 485

  Fly   401 FSQSLEDSLACGAFSRDGARFVC-------GGQKG-----QLYL-CDLNGTIVDSWEGV------ 446
            .|.:.::||    ||..|...:.       .|:|.     .||. ...||    :|:.|
Yeast   486 HSLTTKESL----FSLKGRTCIALGHDENISGRKSIDPAKVLYKPTSSNG----NWQYVEDDETF 542

  Fly   447 -RVNSIAFRADNKTILAADNHYRIRGYNFDSPRSDFDILREPHPIMTFSINSADRLAL------- 503
             ||:.:....|:|.:|...:...|..|:|....|..::.::......|.|....||.:
Yeast   543 PRVHDVKISYDDKYVLLMTHQGVIDVYDFSGFPSKEELSKQTVDPKNFLIPRIARLDVGKNMTCI 607

  Fly   504 ---LNVSNQGLH---------------------LWDIEDKCLVRRFQGIRQSNFAIHSCFGGVNE 544
               ||.::||.|                     :||.::..|::::.|.:|.:|.|.|||...|:
Yeast   608 SLPLNTTHQGFHRQQISESQHLVLVSLQDNELQMWDYKENILIQKYFGQKQQHFIIRSCFAYGNK 672

  Fly   545 SFVASGSEDKVVYIWHIKREEPLAKLAGHT-----------KTVNCVSWNPVYPSLLASASDDAT 598
             .|.|||||..:|||...|...::.|:||:           |..|.|:.||....:.||..||..
Yeast   673 -LVMSGSEDGKIYIWDRIRGNLVSVLSGHSTVMSNSTKPMGKNCNVVASNPADKEMFASGGDDGK 736

  Fly   599 VRIW 602
            ::||
Yeast   737 IKIW 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7611	NP_001163489.1	CTLH	129..190	CDD:128914	15/99 (15%)
		WD40	<303..605	CDD:225201	100/446 (22%)
		WD40	307..602	CDD:295369	97/440 (22%)
		WD40 repeat	318..358	CDD:293791	13/47 (28%)
		WD40 repeat	364..402	CDD:293791	13/113 (12%)
		WD40 repeat	410..444	CDD:293791	9/46 (20%)
		WD40 repeat	448..534	CDD:293791	22/116 (19%)
		WD40 repeat	577..602	CDD:293791	8/24 (33%)
GID7	NP_009891.1	WD40	318..741	CDD:421866	100/444 (23%)
		WD40 repeat	327..369	CDD:293791	13/49 (27%)
		WD40 repeat	375..424	CDD:293791	8/48 (17%)
		WD40 repeat	459..498	CDD:293791	9/43 (21%)
		WD40 repeat	537..610	CDD:293791	13/72 (18%)
		WD40 repeat	617..654	CDD:293791	5/36 (14%)
		WD40 repeat	662..708	CDD:293791	18/46 (39%)
		WD40 repeat	715..740	CDD:293791	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0293
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1272
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002691
OrthoInspector	1	1.000	-	-		oto98949
orthoMCL	1	0.900	-	-		OOG6_102395
Panther	1	1.100	-	-	LDO	PTHR22838
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1892
SonicParanoid	1	1.000	-	-		X1793
TreeFam	0	0.000	Not matched by this tool.
	10	9.910