DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7611 and WDR26

DIOPT Version :9

Sequence 1:	NP_001163489.1	Gene:	CG7611 / 40386	FlyBaseID:	FBgn0037094	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001366332.1	Gene:	WDR26 / 80232	HGNCID:	21208	Length:	761	Species:	Homo sapiens

Alignment Length:	712	Identity:	334/712 - (46%)
Similarity:	444/712 - (62%)	Gaps:	96/712 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 STSSTSSGSCSRP----------------------------LEGSTLNSGGSAENVARDGGSGDD 39
            |:||:||.|.|..                            :.||.:.:.|:.......||.|..
Human    55 SSSSSSSSSSSSSVVVVVGLPPAAAPPAAAAVPHRSSGHSLVSGSIMQANGAGGGGGGGGGGGGG 119

  Fly    40 SVG----------------IGDENPSGSSAATNGHDSKHNGFI------VNNNGSSSRIVDGENN 82
            ..|                .|:.:||.||:|  |..:..||.:      .:||.:|..:.:|...
Human   120 GGGGGGQGQTPELACLSAQNGESSPSSSSSA--GDLAHANGLLPSAPSAASNNSNSLNVNNGVPG 182

  Fly    83 RENTSCSGV---------------------------QLDKSNQEIIRLIGQYLHDVGLDKSVQTL 120
            ....:.|..                           :|.:|::::||||||:|:.:||:::|..|
Human   183 GAAAASSATVAAASATTAASSSLATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLL 247

  Fly   121 MLESGCYLEHPSATKFREHVLMGDWSKADSDLKDLEPL--------------IDNGKLATITEMK 171
            |.||||.||||||||||.||:.|||.||::||.:|:||              |....|..|..||
Human   248 MQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMK 312

  Fly   172 FILLEQKYLEHLDDGNPLDALHVLRSELTPLQHNITRVHQLSSYMMCSTNQDLYQRAKWEGKGIL 236
            |:||:|||||:|:||..|:||.|||.|||||::|..|:|.||.|:|||..:||..:|:|||||..
Human   313 FLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTA 377

  Fly   237 SRALVMERLQTFMPPSVMMSPRRLRTLLQQAVELQSQHCPCHDMAWETNLETVSLLTDHCCTTDG 301
            ||:.::::|||::|||||:.||||:|||:||||||...|..|:...:.||::||||.||.|:...
Human   378 SRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQ 442

  Fly   302 FPMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDPYKLTLKHRRVLDGQAQLSVSF 366
            ||..|.||||:||:||||||||.||.||||||||:|||||.|||....||..:.|:|.| ..||:
Human   443 FPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHA-YGVSY 506

  Fly   367 VSWSPDSKLILVGGTEDSHELYIWNVDDGKLVVKFSQSLEDSLACGAFSRDGARFVCGGQKGQLY 431
            ::||||...::..|.:|..||::|||..|:|..|.|||.||||...|::.||.|||.|||:||.|
Human   507 IAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFY 571

  Fly   432 LCDLNGTIVDSWEGVRVNSIAFRADNKTILAADNHYRIRGYNFDSPRSDFDILREPHPIMTFSIN 496
            .|||:|.::||||||||..:...:|.||:||:|.|.|||||||:. .:|.:|::|.||||:|:|:
Human   572 QCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFED-LTDRNIVQEDHPIMSFTIS 635

  Fly   497 SADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQSNFAIHSCFGGVNESFVASGSEDKVVYIWHI 561
            ...|||||||:.||:||||::|:.|||::||:.|..:.|||||||.||.|:||||||..|||||.
Human   636 KNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHK 700

  Fly   562 KREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIWGPKPNGSSATTESDDCSSSSS 623
            :.|.|:|:|.|||:|||||||||..||::||||||.|||||||.|.......| ::|||..|
Human   701 RSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIE-EECSSMDS 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7611	NP_001163489.1	CTLH	129..190	CDD:128914	37/74 (50%)
		WD40	<303..605	CDD:225201	180/301 (60%)
		WD40	307..602	CDD:295369	175/294 (60%)
		WD40 repeat	318..358	CDD:293791	27/39 (69%)
		WD40 repeat	364..402	CDD:293791	16/37 (43%)
		WD40 repeat	410..444	CDD:293791	18/33 (55%)
		WD40 repeat	448..534	CDD:293791	44/85 (52%)
		WD40 repeat	577..602	CDD:293791	19/24 (79%)
WDR26	NP_001366332.1	LisH_TPL	226..253	CDD:375350	14/26 (54%)
		CTLH	256..331	CDD:128914	37/74 (50%)
		WD40	449..741	CDD:238121	175/293 (60%)
		WD40 repeat	459..499	CDD:293791	27/39 (69%)
		WD40 repeat	504..542	CDD:293791	16/37 (43%)
		WD40 repeat	550..584	CDD:293791	18/33 (55%)
		WD40 repeat	588..633	CDD:293791	22/45 (49%)
		WD40 repeat	642..710	CDD:293791	41/67 (61%)
		WD40 repeat	716..741	CDD:293791	19/24 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159444
Domainoid	1	1.000	207	1.000	Domainoid score	I2906
eggNOG	1	0.900	-	-		E1_KOG0293
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11857
Inparanoid	1	1.050	628	1.000	Inparanoid score	I860
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54864
OrthoDB	1	1.010	-	-		D296923at33208
OrthoFinder	1	1.000	-	-		FOG0002691
OrthoInspector	1	1.000	-	-		oto88345
orthoMCL	1	0.900	-	-		OOG6_102395
Panther	1	1.100	-	-	LDO	PTHR22838
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770