Protein Alignment CG7611 and WDR26

DIOPT Version :10

• Sequence 1: NP_649326.1
• Gene: CG7611 / 40386
• FlyBaseID: FBgn0037094
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001366332.1
• Gene: WDR26 / 80232
• HGNCID: 21208
• Length: 761
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 334/712 - (46%)
• Similarity: 444/712 - (62%)
• Gaps: 96/712 - (13%)

  Fly     3 STSSTSSGSCSRP----------------------------LEGSTLNSGGSAENVARDGGSGDD 39
            |:||:||.|.|..                            :.||.:.:.|:.......||.|..
Human    55 SSSSSSSSSSSSSVVVVVGLPPAAAPPAAAAVPHRSSGHSLVSGSIMQANGAGGGGGGGGGGGGG 119

  Fly    40 SVG----------------IGDENPSGSSAATNGHDSKHNGFI------VNNNGSSSRIVDGENN 82
            ..|                .|:.:||.||:|  |..:..||.:      .:||.:|..:.:|...
Human   120 GGGGGGQGQTPELACLSAQNGESSPSSSSSA--GDLAHANGLLPSAPSAASNNSNSLNVNNGVPG 182

  Fly    83 RENTSCSGV---------------------------QLDKSNQEIIRLIGQYLHDVGLDKSVQTL 120
            ....:.|..                           :|.:|::::||||||:|:.:||:::|..|
Human   183 GAAAASSATVAAASATTAASSSLATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLL 247

  Fly   121 MLESGCYLEHPSATKFREHVLMGDWSKADSDLKDLEPL--------------IDNGKLATITEMK 171
            |.||||.||||||||||.||:.|||.||::||.:|:||              |....|..|..||
Human   248 MQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMK 312

  Fly   172 FILLEQKYLEHLDDGNPLDALHVLRSELTPLQHNITRVHQLSSYMMCSTNQDLYQRAKWEGKGIL 236
            |:||:|||||:|:||..|:||.|||.|||||::|..|:|.||.|:|||..:||..:|:|||||..
Human   313 FLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTA 377

  Fly   237 SRALVMERLQTFMPPSVMMSPRRLRTLLQQAVELQSQHCPCHDMAWETNLETVSLLTDHCCTTDG 301
            ||:.::::|||::|||||:.||||:|||:||||||...|..|:...:.||::||||.||.|:...
Human   378 SRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQ 442

  Fly   302 FPMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDPYKLTLKHRRVLDGQAQLSVSF 366
            ||..|.||||:||:||||||||.||.||||||||:|||||.|||....||..:.|:|.| ..||:
Human   443 FPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHA-YGVSY 506

  Fly   367 VSWSPDSKLILVGGTEDSHELYIWNVDDGKLVVKFSQSLEDSLACGAFSRDGARFVCGGQKGQLY 431
            ::||||...::..|.:|..||::|||..|:|..|.|||.||||...|::.||.|||.|||:||.|
Human   507 IAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFY 571

  Fly   432 LCDLNGTIVDSWEGVRVNSIAFRADNKTILAADNHYRIRGYNFDSPRSDFDILREPHPIMTFSIN 496
            .|||:|.::||||||||..:...:|.||:||:|.|.|||||||:. .:|.:|::|.||||:|:|:
Human   572 QCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFED-LTDRNIVQEDHPIMSFTIS 635

  Fly   497 SADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQSNFAIHSCFGGVNESFVASGSEDKVVYIWHI 561
            ...|||||||:.||:||||::|:.|||::||:.|..:.|||||||.||.|:||||||..|||||.
Human   636 KNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHK 700

  Fly   562 KREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIWGPKPNGSSATTESDDCSSSSS 623
            :.|.|:|:|.|||:|||||||||..||::||||||.|||||||.|.......| ::|||..|
Human   701 RSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIE-EECSSMDS 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7611	NP_649326.1	LisH_TPL	98..126	CDD:375350	14/27 (52%)
		CTLH	129..190	CDD:128914	37/74 (50%)
		WD40	<305..602	CDD:441893	176/296 (59%)
		WD40 repeat	318..358	CDD:293791	27/39 (69%)
		WD40 repeat	364..402	CDD:293791	16/37 (43%)
		WD40 repeat	410..444	CDD:293791	18/33 (55%)
		WD40 repeat	448..534	CDD:293791	44/85 (52%)
		WD40 repeat	577..602	CDD:293791	19/24 (79%)
WDR26	NP_001366332.1	LisH_TPL	226..253	CDD:375350	14/26 (54%)
		CTLH	256..331	CDD:128914	37/74 (50%)
		WD40	<447..741	CDD:441893	176/295 (60%)
		WD40 repeat	459..499	CDD:293791	27/39 (69%)
		WD40 repeat	504..542	CDD:293791	16/37 (43%)
		WD40 repeat	550..584	CDD:293791	18/33 (55%)
		WD40 repeat	588..633	CDD:293791	22/45 (49%)
		WD40 repeat	642..710	CDD:293791	41/67 (61%)
		WD40 repeat	716..741	CDD:293791	19/24 (79%)