DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7611 and wdr26a

DIOPT Version :9

Sequence 1:	NP_001163489.1	Gene:	CG7611 / 40386	FlyBaseID:	FBgn0037094	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_001921656.6	Gene:	wdr26a / 559461	ZFINID:	ZDB-GENE-111027-4	Length:	590	Species:	Danio rerio

Alignment Length:	594	Identity:	312/594 - (52%)
Similarity:	422/594 - (71%)	Gaps:	20/594 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GIGDENPSGSSAATNGHDSKHNGFIVNNNGSSSRIVDGENNRENTSC------SGV----QLDKS 96
            |.|.:.|....:..||..|......|::||    ::...||...:|.      :|:    :|.:|
Zfish     5 GTGGQEPEPQLSCRNGESSSSAAGAVHSNG----LLSSANNGLPSSTESPAPDTGMKKKKRLSQS 65

  Fly    97 NQEIIRLIGQYLHDVGLDKSVQTLMLESGCYLEHPSATKFREHVLMGDWSKADSDLKDLEPLIDN 161
            ::::||||||:||.:||:::|..||.||||.||||||||||.||:.|:|.||:|||.:|:.|:.:
Zfish    66 DEDVIRLIGQHLHGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGEWEKAESDLNELKALMHS 130

  Fly   162 GKLATITEMKFILLEQKYLEHLDDGNPLDALHVLRSELTPLQHNITRVHQLSSYMMCSTNQDLYQ 226
            .  :.:..|||:||:|||||:|:|...|:||.|||||||||::|..|:|.||.|:|||.::||..
Zfish   131 P--SAVVRMKFLLLQQKYLEYLEDAKVLEALQVLRSELTPLKYNTERIHVLSGYLMCSNSEDLRL 193

  Fly   227 RAKWEGKGILSRALVMERLQTFMPPSVMMSPRRLRTLLQQAVELQSQHCPCHDMAWETNLETVSL 291
            :|:|||||..||:.::::|||::|||||:.||||:|||:||||||...|..|:...::.|:.|||
Zfish   194 KAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDSGLDNVSL 258

  Fly   292 LTDHCCTTDGFPMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDPYKLTLKHRRVL 356
            |.||.|:...||..|.||||:||:||||||||.||.|||:||||:|||||.|||....||..:.|
Zfish   259 LIDHVCSRKQFPCYTQQILTEHCNEVWFCKFSNDGTKLASGSKDTTVIIWQVDPDSQQLKQLKTL 323

  Fly   357 DGQAQLSVSFVSWSPDSKLILVGGTEDSHELYIWNVDDGKLVVKFSQSLEDSLACGAFSRDGARF 421
            :|.| ..||:::||||...::..|.:|..||::|||..|:|..|.|||.||||...|::.||.||
Zfish   324 EGHA-YGVSYLAWSPDDTYLIACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRF 387

  Fly   422 VCGGQKGQLYLCDLNGTIVDSWEGVRVNSIAFRADNKTILAADNHYRIRGYNFDSPRSDFDILRE 486
            |.|||:||.|.|||:|.::||||||||..:....|.:|:||:|.|.|||||||:. .:|.:|::|
Zfish   388 VTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLGDGRTVLASDTHQRIRGYNFED-LTDRNIVQE 451

  Fly   487 PHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQSNFAIHSCFGGVNESFVASGS 551
            .||||:|:::...|||||||:.||:||||::|:.|||::||:.|..:.|||||||.||.|:||||
Zfish   452 DHPIMSFTVSKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGYNEDFIASGS 516

  Fly   552 EDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIWGPKPNGSSATTE-- 614
            ||..|||||.:.|.|:|:|.|||:||||||||||.|.|:||||||.|||:|||.|...|..|:
Zfish   517 EDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPVLPGLMASASDDGTVRVWGPAPFLDSQDTDGL 581

  Fly   615 SDDCSSSSS 623
            :.:|.|..|
Zfish   582 TVECYSMDS 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7611	NP_001163489.1	CTLH	129..190	CDD:128914	32/60 (53%)
		WD40	<303..605	CDD:225201	177/301 (59%)
		WD40	307..602	CDD:295369	173/294 (59%)
		WD40 repeat	318..358	CDD:293791	26/39 (67%)
		WD40 repeat	364..402	CDD:293791	16/37 (43%)
		WD40 repeat	410..444	CDD:293791	18/33 (55%)
		WD40 repeat	448..534	CDD:293791	42/85 (49%)
		WD40 repeat	577..602	CDD:293791	20/24 (83%)
wdr26a	XP_001921656.6	CTLH	98..157	CDD:128914	32/60 (53%)
		WD40	275..567	CDD:238121	173/293 (59%)
		WD40 repeat	285..325	CDD:293791	26/39 (67%)
		WD40 repeat	330..368	CDD:293791	16/37 (43%)
		WD40 repeat	376..410	CDD:293791	18/33 (55%)
		WD40 repeat	414..459	CDD:293791	21/45 (47%)
		WD40 repeat	468..536	CDD:293791	41/67 (61%)
		WD40 repeat	542..567	CDD:293791	20/24 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595615
Domainoid	1	1.000	200	1.000	Domainoid score	I2990
eggNOG	1	0.900	-	-		E1_KOG0293
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	614	1.000	Inparanoid score	I870
OMA	1	1.010	-	-		QHG54864
OrthoDB	1	1.010	-	-		D296923at33208
OrthoFinder	1	1.000	-	-		FOG0002691
OrthoInspector	1	1.000	-	-		otm24960
orthoMCL	1	0.900	-	-		OOG6_102395
Panther	1	1.100	-	-	LDO	PTHR22838
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1892
SonicParanoid	1	1.000	-	-		X1793
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800