Protein Alignment Cdk12 and CDK1

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001777.1
• Gene: CDK1 / 983
• HGNCID: 1722
• Length: 297
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 128/309 - (41%)
• Similarity: 188/309 - (60%)
• Gaps: 31/309 - (10%)

  Fly   804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHE 868
            :..|.:|||||||.|||.|...|..:||:||:|||.|:||.|.||:|||.:|::|.|.|||:|.:
Human     4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68

  Fly   869 IVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMK----QLLDGLNYCHK 929
            ::  .||:        ..||:||::..||...|:|  :...:..::|::|    |:|.|:.:||.
Human    69 VL--MQDS--------RLYLIFEFLSMDLKKYLDS--IPPGQYMDSSLVKSYLYQILQGIVFCHS 121

  Fly   930 KNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPS 994
            :..||||:|..|:|::::|.:|||||||||.:...  .|.||::|:|||||.||:|||..||...
Human   122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVVTLWYRSPEVLLGSARYSTP 184

  Fly   995 IDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLF-HTLKQKK---- 1054
            :|:||.|.|..||..|:|||..::|:.||..|.:..|:|...|||.|..|..: :|..:.|
Human   185 VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSL 249

  Fly  1055 -THRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKIN 1102
             :|.:.|.|:       .||||.|||..||.|||:.:.||..|:...::
Human   250 ASHVKNLDEN-------GLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	128/303 (42%)
CDK1	NP_001777.1	STKc_CDK1_euk	3..287	CDD:270845	128/303 (42%)