Protein Alignment Cdk12 and SGV1

DIOPT Version :9

• Sequence 1: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_015487.1
• Gene: SGV1 / 856290
• SGDID: S000006365
• Length: 657
• Species: Saccharomyces cerevisiae
• Alignment Length: 437
• Identity: 152/437 - (34%)
• Similarity: 231/437 - (52%)
• Gaps: 72/437 - (16%)

  Fly   737 PPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNV-------- 793
            |.|:|.:|              |:...:|.|          :..|.|  :||::.|:
Yeast     7 PAVLPKTE--------------FNKYKIGKV----------KSTPAI--QRDAKTNLTYIKLRKR 45

  Fly   794 ---RDWGERCVDVFE----MIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVRE 851
               :.:|  |. ||:    ...::|:||:|:|||.....|...||:||:.:..||:.|||||.||
Yeast    46 SSEKVYG--CT-VFQNHYREDEKLGQGTFGEVYKGIHLETQRQVAMKKIIVSVEKDLFPITAQRE 107

  Fly   852 IKILRQLNHRNIVNLHEIVTDKQ----DAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEEN 912
            |.||::|||:||:.|.|:|.|..    :|......| |||::..||..||.|:|.:..::....:
Yeast   108 ITILKRLNHKNIIKLIEMVYDHSPDITNAASSNLHK-SFYMILPYMVADLSGVLHNPRINLEMCD 171

  Fly   913 NASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNA--DDRERP------ 969
            ..::|.|:|:||||.|...|:|||||.:|||:::.|.:|||||||||||..  .:.:.|
Yeast   172 IKNMMLQILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYYGCPPNLKYPGGAGSG 236

  Fly   970 --YTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGS 1032
              ||:.|:|.|||.|||:||:::|..::|:|..||:..|.|.|:|:.|...::.|...|.|:.|:
Yeast   237 AKYTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFFEKKPILQGKTDIDQGHVIFKLLGT 301

  Fly  1033 PVPAVWPNVIKLP--LFHTLKQKKTHRRRLREDF-EFMPAPALDLLDKMLDLDPDKRITAEDALR 1094
            |....|.....||  ...|...|.|    |||.| :::....||.|.::|.|||.||:||..|..
Yeast   302 PTEEDWAVARYLPGAELTTTNYKPT----LRERFGKYLSETGLDFLGQLLALDPYKRLTAMSAKH 362

  Fly  1095 SPWLRKINPDEMPTPQ--LPTWQDCHELWSKKRRRQMREQQESLPPT 1139
            .||.::   |.:|:.:  ||| ::.||...|:.:.:|.:......||
Yeast   363 HPWFKE---DPLPSEKITLPT-EESHEADIKRYKEEMHQSLSQRVPT 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	128/322 (40%)
		S_TKc	804..1098	CDD:214567	125/314 (40%)
SGV1	NP_015487.1	STKc_BUR1	50..366	CDD:270849	128/323 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840