Protein Alignment Cdk12 and SMK1

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_015379.1
• Gene: SMK1 / 856167
• SGDID: S000006258
• Length: 388
• Species: Saccharomyces cerevisiae
• Alignment Length: 359
• Identity: 113/359 - (31%)
• Similarity: 169/359 - (47%)
• Gaps: 56/359 - (15%)

  Fly   775 GTTRQRPVILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQV----YKARDHHTNDMVALKKV 835
            |..:||.:....|.|          ....:|:|..:|:|.||.|    :|.|.....  :|:||:
Yeast    19 GAPQQRTIFAKERIS----------IPGYYEIIQFLGKGAYGTVCSVKFKGRSPAAR--IAVKKI 71

  Fly   836 RLEHEKEGFPITAVREIKILRQL-NHRNIVNL--HEIVTDKQDAVEFRKDKGSFYLVFEYMDHDL 897
            .....||.....|:||:|.:... .|:|||||  .||||.        ......|...|.:|:||
Yeast    72 SNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTS--------SPYDGLYCYQELIDYDL 128

  Fly   898 MGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLAR--- 959
            ..::.|. |..:|.:....:.|:|.||.|.|..:.:|||:|..|||....|.:|:.||||||
Yeast   129 AKVIHSS-VQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIH 192

  Fly   960 --LYNADDRERPY-TNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMA 1021
              .:......:|: ||.|.|.|||.|||||..:.|..|:|:|:.||||.|.:.::|:|.....|.
Yeast   193 AGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMH 257

  Fly  1022 QLETISKICGSPVPAVWPNVIKLPLFHTLK------------QKKTHRRRLREDFEFMPAPALDL 1074
            |:..|.|:.|:|...:   :||   |.|:|            .||.....:   |.|....|::|
Yeast   258 QIFEIIKVLGTPDKDI---LIK---FGTIKAWNLGKNSNNPVYKKIPWSNI---FPFASHEAINL 313

  Fly  1075 LDKMLDLDPDKRITAEDALRSPWLRKI-NPDEMP 1107
            ::.:|..|...|:..|.|:..|:|.:: .||:.|
Yeast   314 IESLLHWDSTHRLNVEQAISHPFLNEVRKPDDEP 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	104/326 (32%)
SMK1	NP_015379.1	Protein Kinases, catalytic domain	37..376	CDD:473864	108/331 (33%)