Protein Alignment Cdk12 and PHO85

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_015294.1
• Gene: PHO85 / 856076
• SGDID: S000005952
• Length: 305
• Species: Saccharomyces cerevisiae
• Alignment Length: 303
• Identity: 118/303 - (38%)
• Similarity: 182/303 - (60%)
• Gaps: 22/303 - (7%)

  Fly   804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHE 868
            |:.:.::|.|||..|||..:..|...||||:|:|:.| ||.|.||:|||.::::|.|.|||.|::
Yeast     7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHENIVRLYD 70

  Fly   869 IVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEEN-NASIMK----QLLDGLNYCH 928
            ::          ..:....||||:||:||...::|..|...... ..:::|    |||.||.:||
Yeast    71 VI----------HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125

  Fly   929 KKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGP 993
            :...||||:|..|:|:|.||::||.||||||.:...  ...::::|:|||||.|::|:|...|..
Yeast   126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP--VNTFSSEVVTLWYRAPDVLMGSRTYST 188

  Fly   994 SIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHR- 1057
            |||:|||||||.|:...:|||....:..||:.|..|.|:|..::||:|.|||.::...|::..|
Yeast   189 SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRD 253

  Fly  1058 -RRLREDF--EFMPAPALDLLDKMLDLDPDKRITAEDALRSPW 1097
             |::.:..  |.:....:|.|..:|.|:||.|::|:.||..||
Yeast   254 LRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	118/303 (39%)
PHO85	NP_015294.1	Protein Kinases, catalytic domain	6..297	CDD:473864	118/303 (39%)