DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk12 and FPK1

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_014445.1	Gene:	FPK1 / 855783	SGDID:	S000005330	Length:	893	Species:	Saccharomyces cerevisiae

Alignment Length:	1087	Identity:	224/1087 - (20%)
Similarity:	368/1087 - (33%)	Gaps:	359/1087 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 KRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAPSKSNERTVSAA 200
            ::::..:::|:|.|.::                                    |:..:|||.|.:
Yeast     9 EQERDHEQEHEHDSLQR------------------------------------PTTGSERTRSIS 37

  Fly   201 PSSFTPHNLKESSSPATPPPVRRPNTNSNYYGESSLETANSALGSNLQVTVTNKQSISNRLRSPP 265
            .|.....:.|.::|            :||                |:.|:..|       |.|.|
Yeast    38 FSKLLTRSWKRNAS------------SSN----------------NMSVSSVN-------LYSDP 67

  Fly   266 PSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSR-SSRYVNSPHKEDVSAHHRSSHD 329
            .:||.                |.:::||..|..|    |.|: .|.:.:....::.|||:.|
Yeast    68 ENSRE----------------SDHNNSGSEGQSS----RFSKLKSMFQSGNSSKNASAHNSS--- 109

  Fly   330 HGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPP-----HKRRKFSDGREVGLGNFEHSRH 389
                 :.|..|.|:..:.|::.:.|.....|..|::||     .:.......:.|.:...||.|.
Yeast   110 -----QSSLEGDSASSSSKLRYVKPMTSVANASPASPPLSPTIPETDVLQTPKMVHIDQHEHERE 169

  Fly   390 HS--GKYERYSRDRYS----------RRSSRSPSVQHSRSRQSPSGGL--------SSGSNAFRH 434
            ||  |.....|...:|          |||..:|.:....|..|.|...        .|||..|..
Yeast   170 HSNCGSPIMLSSSSFSPTVARTGTGRRRSPSTPIMPSQNSNNSSSTSAIRPNNYRHHSGSQGFSS 234

  Fly   435 GGSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSP--RTSSRYMESSPPSPVGASGSHHY 497
            ....:.:.||..||.|...                |...|  ..||..::.........||.|..
Yeast   235 NNPFRERAGTVRSSNPYFA----------------YQGLPTHAMSSHDLDEGFQPYANGSGIHFL 283

  Fly   498 HHRRSPRMRQRTRGDSRRRSPSSASSESSASRSRSPTSRDLKHKREEYIKKISETSLFAELVKDR 562
                              .:|:|.::..:.:::.|..|.:...:.||..:..:|...|.::.||
Yeast   284 ------------------STPTSKTNSLTNTKNLSNLSLNEIKENEEVQEFNNEDFFFHDIPKD- 329

  Fly   563 HKRQKALKEIIERQEENSNSNSNGALTIN----------DNSSSVDGNTPNAADGRSAPGSGTPA 617
                .:||:.:.......:|.|.   ||.          ||....|.|.....:...
Yeast   330 ----LSLKDTLNGSPSRGSSKSP---TITQTFPSIIVGFDNEYEEDNNNDKHDEKEE-------- 379

  Fly   618 AASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNN 682
            ..:||.|..:.|.            |.|||.. .::|           ::|.||
Yeast   380 QQTTTDNKTRNLS------------PTKQNGK-ATHP-----------RIKIPL----------- 409

  Fly   683 IKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPGS---E 744
               :...|.|     |.|.||.|.||:     .|..:..:.|.:.|..:....:||  |.|   :
Yeast   410 ---RRAASEP-----NGLQLASATSPT-----SSSARKTSGSSNINDKIPGQSVPP--PNSFFPQ 459

  Fly   745 ELSGDDDVIDSPE--DFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCVDV---- 803
            |        .||:  ||..|                       ||..|...:.:..:..|:
Yeast   460 E--------PSPKISDFPEP-----------------------RRSRRLRTKSFSNKFQDIMVGP 493

  Fly   804 --FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAV-REIKILRQLNHRNIVN 865
              ||.|..:|:|..|:|:..|:..||.:.|||.:..:...:...|..| .|.:||...||..||.
Yeast   494 QSFEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPFIVT 558

  Fly   866 LHEIVTDKQDAVEFRKDKGSFYLVFEY-MDHDLMGLLESGMVDFNEENNASI-MKQLLDGLNYCH 928
            |:.         .|:.: ...||..|| |..:....|::.......|::|.. ..::...|.|.|
Yeast   559 LYH---------SFQSE-DYLYLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLH 613

  Fly   929 KKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPY--------------------TNK 973
            ...|::||:|..|||::..|.:.|:||.|:  ..|.|.:.|.                    ||.
Yeast   614 LLGFIYRDLKPENILLHQSGHIMLSDFDLS--IQAKDSKVPVVKGSAQSTLVDTKICSDGFRTNS 676

  Fly   974 VI-TLWYRPPELLLGEERYGPSIDVWSCGCILGE-LFVKRPLFQANAEMAQLETISKICGSPVPA 1036
            .: |..|..||::.| ..:..::|.|:.|.::.| ||...|....|..    ||.:.|..:.|.
Yeast   677 FVGTEEYIAPEVIRG-NGHTAAVDWWTLGILIYEMLFGFTPFKGDNTN----ETFTNILKNEVS- 735

  Fly  1037 VWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRI----TAEDALRSPW 1097
             :||  ...:..|.|                     ||:.|:|..:..||:    .|.|..:.|:
Yeast   736 -FPN--NNEISRTCK---------------------DLIKKLLTKNESKRLGCKMGAADVKKHPF 776

  Fly  1098 LRKIN----PDEMPTPQLPTWQ----DCHELWSKKRRRQMREQQESL 1136
            .:|:.    .::.| |.:|...    |..:|.|.|:|:..::..:.|
Yeast   777 FKKVQWSLLRNQEP-PLIPVLSEDGYDFAKLSSNKKRQTSQDSHKHL 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	83/336 (25%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	82/322 (25%)
FPK1	NP_014445.1	STKc_phototropin_like	494..797	CDD:270726	86/345 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000