DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk12 and CTK1

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_012783.1	Gene:	CTK1 / 853718	SGDID:	S000001622	Length:	528	Species:	Saccharomyces cerevisiae

Alignment Length:	579	Identity:	185/579 - (31%)
Similarity:	283/579 - (48%)	Gaps:	92/579 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   582 SNSNGALTINDNSSSVDGNTPNAADGRSAPGSGT-----PAAASTTSNGLQALGSKPDLDLNNIP 641
            |.:||    |..|.|...|......|:.:|...:     |.....|.:|.|:
Yeast     2 SYNNG----NTYSKSYSRNNKRPLFGKRSPNPQSLARPPPPKRIRTDSGYQS------------- 49

  Fly   642 MPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGAR 706
                ..|::.|:..::.|.|....           |...||:...:.||........     |:|
Yeast    50 ----NMDNISSHRVNSNDQPGHTK-----------SRGNNNLSRYNDTSFQTSSRYQ-----GSR 94

  Fly   707 SPSPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPEDF-DAPAVGTVHGH 770
            ..:.....|:..|::....:..:.:.:||..   |.|.|.|..::..::..|. :.......:.|
Yeast    95 YNNNNTSYENRPKSIKRDETKAEFLSHLPKG---PKSVEKSRYNNSSNTSNDIKNGYHASKYYNH 156

  Fly   771 GGGPGTT---RQRPV-ILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVA 831
            .|..|.:   ::.|| :|.:           :|...|:..|.|:||||||:||||::.:|..:||
Yeast   157 KGQEGRSVIAKKVPVSVLTQ-----------QRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVA 210

  Fly   832 LKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHD 896
            |||:||:.|:||||||::||||:|:..:|.|:..:.||:.:.|..|         |::|||.|:|
Yeast   211 LKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQKTV---------YMIFEYADND 266

  Fly   897 LMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLY 961
            |.|||.:..|..:......:.||||.|:.|.|....||||:|.||||::|:|.:|:.||||||..
Yeast   267 LSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKM 331

  Fly   962 NADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETI 1026
            |:   ...|||:||||||||||||||...||..:|:|.|||:|.|||.|..:||.:.|:.|:|:|
Yeast   332 NS---RADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESI 393

  Fly  1027 SKICGSPVPAVWPNVIKLPLFHTLKQKKTHR--RRLREDFE-FMP-APALDLLDKMLDLDPDKRI 1087
            .||.|:|....||.:..:|.|..:..::|.:  ....|.|: .:| :..|.|...:|..|..||.
Yeast   394 FKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRF 458

  Fly  1088 TAEDALRSPWLRKINPDEMPTPQ---LPTWQDCHELWSKKRRRQMREQQESLPPTVIAS 1143
            :|.:||:|.:.:     |.|.|:   |.....|||...|..|:|.|       |.::::
Yeast   459 SATEALQSDYFK-----EEPKPEPLVLDGLVSCHEYEVKLARKQKR-------PNILST 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	134/305 (44%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	132/297 (44%)
CTK1	NP_012783.1	STKc_CDK9_like	183..469	CDD:270832	132/297 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I332
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		oto99345
orthoMCL	1	0.900	-	-		OOG6_101677
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X546
TreeFam	0	0.000	Not matched by this tool.
	9	8.810