Protein Alignment Cdk12 and SWE1

DIOPT Version :9

• Sequence 1: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_012348.1
• Gene: SWE1 / 853252
• SGDID: S000003723
• Length: 819
• Species: Saccharomyces cerevisiae
• Alignment Length: 740
• Identity: 146/740 - (19%)
• Similarity: 271/740 - (36%)
• Gaps: 215/740 - (29%)

  Fly   355 ELDRYNHQPSTPPHKRR--KFSDGR--------EVGLGNFEHSRHHS---GKYERYSRDRYSRRS 406
            |.|.:....|||.:|.:  .:|:.:        .:.|.|...|..:|   ||.|....:....:.
Yeast    35 ESDDFAIGGSTPTNKLKFYPYSNNKLTRSTGTLNLSLSNTALSEANSKFLGKIEEEEEEEEEGKD 99

  Fly   407 SRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYS 471
            ..  ||.....|.||               .|:::         |.||..:||:
Yeast   100 EE--SVDSRIKRWSP---------------FHENE---------SVTTPITKRS----------- 127

  Fly   472 RSPRTSSRYMESSPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRSRSP-TS 535
             :.:|:         ||:...   .::.|..|      :.|:|..:.||:||.|.|..::|. ||
Yeast   128 -AEKTN---------SPISLK---QWNQRWFP------KNDARTENTSSSSSYSVAKPNQSAFTS 173

  Fly   536 RDLKHKREEYIKKIS-ETSLF-------------AELVKDRHKRQKALKEIIERQEENSNSNSNG 586
            ..|       :.|:| :|||:             :.||:.|..:...|         :|:.|::.
Yeast   174 SGL-------VSKMSMDTSLYPAKLRIPETPVKKSPLVEGRDHKHVHL---------SSSKNASS 222

  Fly   587 ALTIN------DNSSSVDGNTPNAADGRSAPGSGTPAAAS---------------------TTSN 624
            :|:::      ||:...|....::...::.|....|...|                     :.:|
Yeast   223 SLSVSPLNFVEDNNLQEDLLFSDSPSSKALPSIHVPTIDSSPLSEAKYHAHDRHNNQTNILSPTN 287

  Fly   625 GLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNNIKPKSLT 689
            .|....|...|..|......:..:||:   ..|.::.:|:.|.|..|    :...:|
Yeast   288 SLVTNSSPQTLHSNKFKKIKRARNSVI---LKNRELTNSLQQFKDDL----YGTDEN-------- 337

  Fly   690 SLPLPPGMNVLDLAGAR-SPSPGQ---KKESDEKNVTSSGSANKSVLNLPMPPVIPGSEELSGDD 750
               .||.:.:......| :|.|.|   :.::|.....|:.:..||::. ........|..||...
Yeast   338 ---FPPPIIISSHHSTRKNPQPYQFRGRYDNDTDEEISTPTRRKSIIG-ATSQTHRESRPLSLSS 398

  Fly   751 DVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTY 815
            .::.:....:..::.:.   ...|..:::|.:..|:..:..:     ....:.|..:..||:|.:
Yeast   399 AIVTNTTSAETHSISST---DSSPLNSKRRLISSNKLSANPD-----SHLFEKFTNVHSIGKGQF 455

  Fly   816 GQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQ------ 874
            ..||:.....||...|:|.::  ..|.......:.|||||.::.       ::|..|::
Yeast   456 STVYQVTFAQTNKKYAIKAIK--PNKYNSLKRILLEIKILNEVT-------NQITMDQEGKEYII 511

  Fly   875 DAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVD-FNEENNASIMKQLLD------------GLNY 926
            |.:...|.:.|:|::.|        |.|:|.:| |.:|...:..|:|.|            .|.:
Yeast   512 DYISSWKFQNSYYIMTE--------LCENGNLDGFLQEQVIAKKKRLEDWRIWKIIVELSLALRF 568

  Fly   927 CHKK-NFLHRDIKCSNILMNNRGKVKLADFGLA--------RLYNADDRERPYTNKVITLWYRPP 982
            .|.. :.:|.|:|.:|:::...|.:||.|||:|        ...|..|||           |..|
Yeast   569 IHDSCHIVHLDLKPANVMITFEGNLKLGDFGMATHLPLEDKSFENEGDRE-----------YIAP 622

  Fly   983 ELLLGEERYGPSIDVWSCGCILGEL 1007
            | ::.:..|....|::|.|.::.|:
Yeast   623 E-IISDCTYDYKADIFSLGLMIVEI 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	57/240 (24%)
		S_TKc	804..1098	CDD:214567	57/232 (25%)
SWE1	NP_012348.1	PTKc_Wee1_fungi	443..791	CDD:270954	57/233 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	56	1.000	Inparanoid score	I1799
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050