Protein Alignment Cdk12 and KIN28

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_010175.1
• Gene: KIN28 / 851450
• SGDID: S000002266
• Length: 306
• Species: Saccharomyces cerevisiae
• Alignment Length: 304
• Identity: 98/304 - (32%)
• Similarity: 160/304 - (52%)
• Gaps: 19/304 - (6%)

  Fly   809 QIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDK 873
            ::|||||..||....|.|...:|:|:::....|:|..::|:||:|.|:::.|.|::.|.:|....
Yeast    12 KVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAY 76

  Fly   874 QDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIK 938
            .          :..||.|::..||..:::...:.|...:..:.|...|.|:.:||:...||||:|
Yeast    77 D----------NLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLK 131

  Fly   939 CSNILMNNRGKVKLADFGLARLYNADDRERPY---TNKVITLWYRPPELLLGEERYGPSIDVWSC 1000
            .:|:|.:..|::|:|||||||...|     |:   |:.|:|.|||.||||.|.:.|..:||:||.
Yeast   132 PNNLLFSPDGQIKVADFGLARAIPA-----PHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSV 191

  Fly  1001 GCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLK-QKKTHRRRLREDF 1064
            |.|..||.::.|......::.|:|...:..|:|....||.|.....::.|: .....|..||:.|
Yeast   192 GVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRF 256

  Fly  1065 EFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPT 1108
            ......|||.:..||.::|.||.||...|.|.:.:::.|...|:
Yeast   257 IAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPS 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	96/292 (33%)
KIN28	NP_010175.1	STKc_CDK7	7..302	CDD:270833	98/304 (32%)