DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk12 and AT1G71530

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_177308.3	Gene:	AT1G71530 / 843493	AraportID:	AT1G71530	Length:	655	Species:	Arabidopsis thaliana

Alignment Length:	502	Identity:	176/502 - (35%)
Similarity:	253/502 - (50%)	Gaps:	72/502 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 SNPASNADVPDSVAQLKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVL--DLAGARSPSPGQKK 714
            |...::.|:.||...:.|.|...|.|:|.::.|..|.|.......:.::  ....||.||
plant    12 SAAVTDKDLLDSSKSILQLLPHHPPSSSSSSKKEGSFTRTTSSASITIVANGYPVARRPS----- 71

  Fly   715 ESDEKNVTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQ 779
            .|.::|.|.             |.|:.|:...:....|...|  ...||              :|
plant    72 TSSDRNSTK-------------PVVVVGAPTRNPTRRVTAIP--VAQPA--------------QQ 107

  Fly   780 RP--VILNRRD-------------SRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDM 829
            :|  ||.|:.:             :...::.|..||.:.||.:.:||:|||..||||||..|..:
plant   108 QPARVISNKTELPAAEWPSWLASVAGEAIKGWVPRCAESFEKLDKIGQGTYSSVYKARDLETGKI 172

  Fly   830 VALKKVR---LEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFE 891
            ||:||||   ::.|...|   ..|||.|||:|:|.|::.|..:||.:.        .||.|||||
plant   173 VAMKKVRFVNMDPESVRF---MAREILILRKLDHPNVMKLEGLVTSRL--------SGSLYLVFE 226

  Fly   892 YMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFG 956
            ||:|||.||..:..:.|:|......|:||..||.:||::..||||||.||:|:||.|.:|:.|||
plant   227 YMEHDLAGLAATPGIKFSEPQIKCYMQQLFRGLEHCHRRGILHRDIKGSNLLINNEGVLKIGDFG 291

  Fly   957 LARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMA 1021
            ||..|..|. :...|::|:|||||.||||||...|||:||:||.||||.|||..:|:.....|:.
plant   292 LANFYRGDG-DLQLTSRVVTLWYRAPELLLGATEYGPAIDLWSAGCILTELFAGKPIMPGRTEVE 355

  Fly  1022 QLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKR 1086
            |:..|.|:||||....|... .|||..:.|....::..|.|.|...|:.||.|::|:|.::|:||
plant   356 QMHKIFKLCGSPSEDYWRRA-TLPLATSFKPSHPYKPVLAETFNHFPSSALMLINKLLAIEPEKR 419

  Fly  1087 ITAEDALRSPWLRKINPDEMPT--PQLPTWQDCHELWSKKRRRQMRE 1131
            .:|...|||.:   ...:.:|.  ..||.:....||.:|.|..:.|:
plant   420 GSAASTLRSEF---FTTEPLPANPSNLPRYPPSKELDAKLRNEEARK 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	137/304 (45%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	134/296 (45%)
AT1G71530	NP_177308.3	STKc_CDK9_like	147..431	CDD:270832	134/299 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		otm2442
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920