DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk12 and AT1G54610

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001117490.1	Gene:	AT1G54610 / 841903	AraportID:	AT1G54610	Length:	572	Species:	Arabidopsis thaliana

Alignment Length:	546	Identity:	182/546 - (33%)
Similarity:	261/546 - (47%)	Gaps:	113/546 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   614 GTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSA 678
            |..||.:||:...||..||                      ||:..|           :|...|.
plant     6 GREAATTTTAEAKQAKSSK----------------------ASSGVV-----------VVGESSV 37

  Fly   679 SKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKN-----VTSSGSANKSVLNLPMPP 738
            :|:|             |:...|:         :||:::|.|     .:|.|...:|  ..|.|.
plant    38 TKSN-------------GVIADDV---------EKKKNEEANGDKERKSSKGDRRRS--TKPNPR 78

  Fly   739 VIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCVDV 803
            :...|:...|:......|..........::|                          |..|..|.
plant    79 LSNPSKHWRGEQVAAGWPSWLSDACGEALNG--------------------------WVPRKADT 117

  Fly   804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEH-EKEGFPITAVREIKILRQLNHRNIVNLH 867
            ||.|.:||:|||..||||:|..|..:|||||||.:: |.|.....| |||.:||:|:|.|:|.|.
plant   118 FEKIDKIGQGTYSNVYKAKDMLTGKIVALKKVRFDNLEPESVKFMA-REILVLRRLDHPNVVKLE 181

  Fly   868 EIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNF 932
            .:||.:...        |.||||:||||||.||..|.:|.|:|.....:|:||:.||.:||.:..
plant   182 GLVTSRMSC--------SLYLVFQYMDHDLAGLASSPVVKFSESEVKCLMRQLISGLEHCHSRGV 238

  Fly   933 LHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDV 997
            ||||||.||:|:::.|.:|:||||||.::: .:.:||.|::|:|||||.||||||...||..||:
plant   239 LHRDIKGSNLLIDDGGVLKIADFGLATIFD-PNHKRPMTSRVVTLWYRAPELLLGATDYGVGIDL 302

  Fly   998 WSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFH--TLKQKKTHRRRL 1060
            ||.||||.||...||:.....|:.||..|.|:||||....|.   |....|  ..|.::.::|.:
plant   303 WSAGCILAELLAGRPIMPGRTEVEQLHKIYKLCGSPSEDYWK---KGKFTHGAIYKPREPYKRSI 364

  Fly  1061 REDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKR 1125
            ||.|:..|..:|.|:|.:|.::|:.|.||..||:|.:... .|.......||.:....|:.:|:|
plant   365 RETFKDFPPSSLPLIDALLSIEPEDRQTASAALKSEFFTS-EPYACEPADLPKYPPSKEIDAKRR 428

  Fly  1126 RRQMREQQESLPPTVIASTKYQQHGA 1151
            ..:.|.|:        |::|.|..||
plant   429 DEETRRQR--------AASKAQGDGA 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	138/304 (45%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	135/296 (46%)
AT1G54610	NP_001117490.1	STKc_CDK9_like	118..402	CDD:270832	135/296 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		otm2442
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920