DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk12 and AT1G03740

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_171870.4	Gene:	AT1G03740 / 839423	AraportID:	AT1G03740	Length:	740	Species:	Arabidopsis thaliana

Alignment Length:	605	Identity:	197/605 - (32%)
Similarity:	290/605 - (47%)	Gaps:	92/605 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 VKDRHK--RQKA--LKEIIERQEENSNSNSNGALTINDNSSSVDG--NTPNAADGRSAPGSGTPA 617
            |..||:  |:|:  ||   |..||..:|..:.:..|:|.....||  ...|:.|.:
plant     4 VNSRHRPFRRKSTTLK---ESSEEKRSSRIDSSRRIDDWIQPEDGFDRLSNSGDAK--------- 56

  Fly   618 AASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNAD----VPDSVAQLKQPLLVPPFSA 678
                    ::.:.|:.   .:.....:.|...::.|||:.|.    |.|...:.....:|.
plant    57 --------VRLIESEM---FSTSRCHDHQIGKILENPATVAHMDRVVHDQELRRASSAVVD---- 106

  Fly   679 SKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKE--SDEKNVTSSGSANKSVLNLPMPPVIP 741
            |..:|.||.:.:        .||    |..|...|..  ..||..:|..|.:..:......|.:.
plant   107 SDLDIDPKVVKA--------KLD----RWNSKDSKVRLIESEKLSSSMFSEHHQIEKGVEKPEVE 159

  Fly   742 GS-----EELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCV 801
            .|     .||.....:: ||:|.:...|.     .|.|.....        .:..::.||..|..
plant   160 ASVRVVHRELKRGSSIV-SPKDAERKQVA-----AGWPSWLVS--------VAGESLVDWAPRRA 210

  Fly   802 DVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLE-HEKEGFPITAVREIKILRQLNHRNIVN 865
            :.||.:.:||:|||..||:|||...|.:|||||||.: ::.|.....| |||.::|:|:|.|::.
plant   211 NTFEKLEKIGQGTYSSVYRARDLLHNKIVALKKVRFDLNDMESVKFMA-REIIVMRRLDHPNVLK 274

  Fly   866 LHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKK 930
            |..::|....:        |.|||||||||||:||.....|.|.|......|:|||.||.:||.:
plant   275 LEGLITAPVSS--------SLYLVFEYMDHDLLGLSSLPGVKFTEPQVKCYMRQLLSGLEHCHSR 331

  Fly   931 NFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSI 995
            ..||||||.||:|::::|.:|:||||||..:: ..:....|:.|:||||||||||||...||..:
plant   332 GVLHRDIKGSNLLIDSKGVLKIADFGLATFFD-PAKSVSLTSHVVTLWYRPPELLLGASHYGVGV 395

  Fly   996 DVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRL 1060
            |:||.|||||||:..:|:.....|:.||..|.|:||||....|... |||.....|....:||::
plant   396 DLWSTGCILGELYAGKPILPGKTEVEQLHKIFKLCGSPTENYWRKQ-KLPSSAGFKTAIPYRRKV 459

  Fly  1061 REDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSK-- 1123
            .|.|:..||..|.||:.:|.:|||.|.:|:.||.|.:. |..|.......||.:....|:.:|
plant   460 SEMFKDFPASVLSLLETLLSIDPDHRSSADRALESEYF-KTKPFACDPSNLPKYPPSKEIDAKMR 523

  Fly  1124 ---KRRRQMR----EQQESL 1136
               ||::.||    |:|:|:
plant   524 DEAKRQQPMRAEKQERQDSM 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	134/302 (44%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	132/294 (45%)
AT1G03740	NP_171870.4	STKc_CDK9_like	213..497	CDD:270832	132/294 (45%)
AT1G03740	NP_171870.4	S_TKc	213..497	CDD:214567	132/294 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2442
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920