DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk12 and AT5G50860

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_199899.1	Gene:	AT5G50860 / 835158	AraportID:	AT5G50860	Length:	580	Species:	Arabidopsis thaliana

Alignment Length:	440	Identity:	155/440 - (35%)
Similarity:	230/440 - (52%)	Gaps:	43/440 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   708 PSPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPE-------DFDAPAVG 765
            |.|...:.:::  :.||.|...:.:::.:     |.::....|.:...||       ||.|
plant    22 PPPADLRNTED--LPSSSSTTTAAISVEI-----GEKKKKDLDSIQIQPERRTWHTGDFSA---- 75

  Fly   766 TVHGHGGGPGTTRQRP------VILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDH 824
               |....||.:.:.|      :|....||   ::|...|....:|.:.:||:|||..||||:|.
plant    76 ---GSSRRPGMSLRTPEGWPPWLIAACGDS---IKDLTPRRATTYEKLEKIGQGTYSNVYKAKDL 134

  Fly   825 HTNDMVALKKVRLEH-EKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYL 888
            .:..:|||||||.:: |.|.....| |||.:||:|||.|::.|..:||.:...        |.||
plant   135 LSGKIVALKKVRFDNLEAESVKFMA-REILVLRRLNHPNVIKLQGLVTSRVSC--------SLYL 190

  Fly   889 VFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLA 953
            |||||:|||.||..:..:.|:.......|||||.||.:||.:..||||||.||:|::|.|.:|:|
plant   191 VFEYMEHDLSGLAATQGLKFDLPQVKCFMKQLLSGLEHCHSRGVLHRDIKGSNLLIDNDGILKIA 255

  Fly   954 DFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANA 1018
            |||||..|:...:: ..|::|:||||||||||||...||..:|:||.|||:.||...:|:.....
plant   256 DFGLATFYDPKQKQ-TMTSRVVTLWYRPPELLLGATSYGTGVDLWSAGCIMAELLAGKPVMPGRT 319

  Fly  1019 EMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDP 1083
            |:.||..|.|:||||..:.|.. .:||.....|.:..::|.:.|.|......::.|::.:|.:||
plant   320 EVEQLHKIFKLCGSPSDSYWKK-YRLPNATLFKPQHPYKRCVAEAFNGFTPSSVHLVETLLTIDP 383

  Fly  1084 DKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQ 1133
            ..|.|:..||.|.:. ...|.......||.:....||..|.|..::|.|:
plant   384 ADRGTSTSALNSEFF-TTEPLPCDPSSLPKYPPSKELNVKLRDEELRRQK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	126/302 (42%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	125/294 (43%)
AT5G50860	NP_199899.1	STKc_CDK9_like	114..398	CDD:270832	125/294 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910