DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk12 and AT5G44290

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001032009.1	Gene:	AT5G44290 / 834452	AraportID:	AT5G44290	Length:	644	Species:	Arabidopsis thaliana

Alignment Length:	485	Identity:	166/485 - (34%)
Similarity:	239/485 - (49%)	Gaps:	82/485 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   694 PPGMNVLDLAGAR------SPSPGQKKESDEKN---------------------VTSSGSANKSV 731
            ||....|:...:|      ..|...|:|.|..|                     :...|..::..
plant    15 PPWKETLEKRSSRINSSRIDDSSQTKEEQDRSNKVRLIESEKFSSSRFSEKHQEIAEIGDTDEDE 79

  Fly   732 LNLPMPPVIPGSEELSGDDDVI--DSPEDFDAPA---------VGTVHGHGGGPGTTRQRPVILN 785
            .:...||     |||..:..|:  .|||.....|         :.:|.|.           .::|
plant    80 DDDHHPP-----EELKREPSVVIPPSPETVSKEAELAAGWPAWLVSVAGE-----------ALVN 128

  Fly   786 RRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLE-HEKEGFPITAV 849
                      |..|....||.:.:||:|||..||||||...|.:||||:||.: .:.|.....|
plant   129 ----------WTPRRASTFEKLEKIGQGTYSSVYKARDLTNNKIVALKRVRFDLSDLESVKFMA- 182

  Fly   850 REIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNA 914
            |||.::|:|:|.|::.|..::|....:        |.|||||||||||:||.....:.|:|....
plant   183 REIIVMRRLDHPNVLKLEGLITASVSS--------SLYLVFEYMDHDLVGLASIPGIKFSEPQVK 239

  Fly   915 SIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWY 979
            ..|:|||.||::||.:..||||||.||:|:::.|.:|:||||||..::..:.. |.|::|:||||
plant   240 CYMQQLLSGLHHCHSRGVLHRDIKGSNLLIDSNGVLKIADFGLATFFDPQNCV-PLTSRVVTLWY 303

  Fly   980 RPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKL 1044
            ||||||||...||..:|:||.|||||||:..:|:.....|:.||..|.|:||||....| ..:||
plant   304 RPPELLLGACHYGVGVDLWSTGCILGELYSGKPILAGKTEVEQLHKIFKLCGSPTEDYW-RKLKL 367

  Fly  1045 PLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTP 1109
            |.....:....:.||:.|.|:.:|...|.||:.:|.:|||:|.:|..||.|.:.| ..|......
plant   368 PPSAAFRPALPYGRRVAEMFKDLPTNVLSLLEALLSIDPDRRGSAARALESEYFR-TEPFACDPS 431

  Fly  1110 QLPTWQDCHELWSK-----KRRRQMREQQE 1134
            .||.:....|:.:|     ||:|..:|:.|
plant   432 SLPKYPPSKEIDAKIRDDAKRQRPTQEKHE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	132/302 (44%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	130/294 (44%)
AT5G44290	NP_001032009.1	STKc_CDK9_like	137..421	CDD:270832	130/294 (44%)
AT5G44290	NP_001032009.1	S_TKc	137..421	CDD:214567	130/294 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2442
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920