DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk12 and AT4G10010

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001328367.1	Gene:	AT4G10010 / 826592	AraportID:	AT4G10010	Length:	649	Species:	Arabidopsis thaliana

Alignment Length:	597	Identity:	195/597 - (32%)
Similarity:	267/597 - (44%)	Gaps:	154/597 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 ELVKDRHKRQKALKEIIERQEENSNSNSNGALTINDNS-------SSVDGNTPNAADGRSAPGSG 614
            |.|.|:|          |:.:||.|..|:..|.....|       .||||    ::.||.|.|
plant    12 EEVSDQH----------EKPKENWNKTSSVQLIAPVTSKKDEFSHKSVDG----SSGGRKADG-- 60

  Fly   615 TPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDS---VVSNPA------SNADVPDSVAQLKQP 670
                          |..||....:.:.:|...:|.   :|..|.      ..||:........
plant    61 --------------LAHKPSARASGLIVPVDDSDGKTVIVERPTRCHRRWPTADIGTGGGGFN-- 109

  Fly   671 LLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTS-SGSANKSVLNL 734
             :.||     :||.    ||:|..|   ..:|..|..||          .:|| :|.|
plant   110 -IFPP-----SNIP----TSVPHSP---EAELIAAGWPS----------WLTSVAGEA------- 144

  Fly   735 PMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGER 799
                                                                      ::.|..|
plant   145 ----------------------------------------------------------IKGWVPR 151

  Fly   800 CVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVR---LEHEKEGFPITAVREIKILRQLNHR 861
            ..:.||.:.:||:|||..||:|||..|..|||:||||   ::.|...|   ..|||.|||:|:|.
plant   152 RAESFEKLDKIGQGTYSSVYRARDLETGKMVAMKKVRFVNMDPESVRF---MAREINILRKLDHP 213

  Fly   862 NIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNY 926
            |::.|..:||.|.        .||.|||||||:|||.||.....|.|.|......|||||.||.:
plant   214 NVMKLECLVTSKL--------SGSLYLVFEYMEHDLSGLALRPGVKFTESQIKCYMKQLLSGLEH 270

  Fly   927 CHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERY 991
            ||.:..||||||..|:|:||.|.:|:.|||||.:|: .::::|.|::|:|||||.||||||...|
plant   271 CHSRGILHRDIKGPNLLVNNDGVLKIGDFGLANIYH-PEQDQPLTSRVVTLWYRAPELLLGATEY 334

  Fly   992 GPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTH 1056
            ||.||:||.||||.|||:.:|:.....|:.|:..|.|.||||....|... ||||..:.|.::.:
plant   335 GPGIDLWSVGCILTELFLGKPIMPGRTEVEQMHKIFKFCGSPSDDYWQKT-KLPLATSFKPQQPY 398

  Fly  1057 RRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELW 1121
            :|.|.|.|:.:|..||.|:||:|.|:|.||.||...|.|.:. .:.|.......||.:....||.
plant   399 KRVLLETFKNLPPSALALVDKLLSLEPAKRGTASSTLSSKFF-TMEPLPCNVSSLPKYPPSKELD 462

  Fly  1122 SKKRRRQMREQQ 1133
            :|.|..:.|.::
plant   463 AKVRDEEARRKK 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	143/304 (47%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	141/296 (48%)
AT4G10010	NP_001328367.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		otm2442
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920