Protein Alignment Cdk12 and Cdk16

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_063136393.1
• Gene: Cdk16 / 81741
• RGDID: 620584
• Length: 708
• Species: Rattus norvegicus
• Alignment Length: 560
• Identity: 178/560 - (31%)
• Similarity: 260/560 - (46%)
• Gaps: 123/560 - (21%)

  Fly   613 SGTPAAASTTSNGLQALGSKP-DLDLNNI---PMPNKQNDSVVSNPASNADVP-DSVAQLKQPL- 671
            |.|.||...:..|:....|:. .|:.||:   |:|:      .|:|:.:..|. |.:.::|:.|
  Rat    36 SVTAAAPEDSCCGVLCSHSETIALETNNLLSGPLPS------ASHPSLSTQVAMDRMKKIKRQLS 94

  Fly   672 --LVPPFSASKNNIKPK-------------SLTSLP--LPPGMNVLDLAGARSPSP--------- 710
              |.......|.|..|:             .|...|  :.|| .:..:.|..|.:|
  Rat    95 MTLRGGRGIDKTNGVPEQIGLDESGGGGGSDLGEAPTRVAPG-ELRSIRGPLSSAPEIVHEDMKM 158

  Fly   711 GQKKESDEKNVTSSGSANKSV--------------------LNLPMPPVIPGS--EELSGDDDVI 753
            |...|||:.:.|||......|                    |:||....:|..  |:|:.:..:.
  Rat   159 GSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIF 223

  Fly   754 DSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQV 818
            |.|                           |:||..|.::.:.|...::.:..:.::|||||..|
  Rat   224 DKP---------------------------LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATV 261

  Fly   819 YKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIV-TDKQDAVEFRKD 882
            ||.:...|:::||||::||||| ||.|.||:||:.:|:.|.|.|||.||:|: |:|
  Rat   262 YKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTEK--------- 316

  Fly   883 KGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNR 947
              |..|||||:|.||...|:......|..|....:.|||.||.|||::..||||:|..|:|:|.|
  Rat   317 --SLTLVFEYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINER 379

  Fly   948 GKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRP 1012
            |::|||||||||..:..  .:.|:|:|:|||||||::|||...|...||:|..|||..|:...||
  Rat   380 GELKLADFGLARAKSIP--TKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 442

  Fly  1013 LFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKK-------THRRRLREDFEFMPAP 1070
            ||..:....||..|.:|.|:|....||.::....|.|....|       :|..||..|
  Rat   443 LFPGSTVEEQLHFIFRILGTPTEDTWPGILSNEEFRTYNYPKYRAEALLSHAPRLDSD------- 500

  Fly  1071 ALDLLDKMLDLDPDKRITAEDALRSPWLRKIN------PD 1104
            ..|||.|:|..:...||:||||::.|:...:.      ||
  Rat   501 GADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPD 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	128/309 (41%)
Cdk16	XP_063136393.1	None