Protein Alignment Cdk12 and cdk15

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_031748614.1
• Gene: cdk15 / 780381
• XenbaseID: XB-GENE-961241
• Length: 435
• Species: Xenopus tropicalis
• Alignment Length: 348
• Identity: 121/348 - (34%)
• Similarity: 177/348 - (50%)
• Gaps: 57/348 - (16%)

  Fly   807 IAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVT 871
            :.::|||:|..|||........:||||.:.::.| ||.|.||:||..:|:.|.|.|||.||:|:.
 Frog   106 LEKLGEGSYATVYKGISRINGQLVALKVISMKAE-EGVPFTAIREGSLLKGLKHANIVLLHDIIQ 169

  Fly   872 DKQDAVEFRKDKGSFYLVFEYMDHDL---MGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFL 933
            .::          :...||||:..||   |.....|::.:|..   ..|.|||.||.|.|.::.|
 Frog   170 TRE----------TLTFVFEYVHTDLAQYMSQHPGGLLPYNVR---LFMFQLLRGLAYIHHQHIL 221

  Fly   934 HRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVW 998
            |||:|..|:|::..|::|||||||||..:..  .:.|:::|:|||||||::|||...|...:|:|
 Frog   222 HRDLKPQNLLISYIGELKLADFGLARAKSIP--SQTYSSEVVTLWYRPPDVLLGATDYSTDLDIW 284

  Fly   999 SCGCILGELFVKRPLFQANAEM-AQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLRE 1062
            ..|||..|:....|.|...::: .|||.|..:.|:|....||.|..||.:      ||....|:
 Frog   285 GAGCIFIEMLQGYPAFSGVSDIFEQLEKIWSVIGTPAEDSWPGVSMLPNY------KTEWLTLQ- 342

  Fly  1063 DFEFMP-----------APALDLLDKMLDLDPDKRITAEDAL-------------RSPWLRKINP 1103
              |:.|           ..|.||.:|||...|.:||:|||||             :.|.:|.|
 Frog   343 --EYQPFGNVWDGLGRSMGAEDLAEKMLKGCPRERISAEDALLHKFFSTLPCQLHQLPDVRSI-- 403

  Fly  1104 DEMPTPQLPTWQDCHELWSKKRR 1126
              ...|.|....:.|:|:...|:
 Frog   404 --FTVPGLSLKPEIHDLYISHRK 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	114/318 (36%)
cdk15	XP_031748614.1	Protein Kinases, catalytic domain	102..387	CDD:473864	113/305 (37%)