Protein Alignment Cdk12 and Cdk13

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_006516829.1
• Gene: Cdk13 / 69562
• MGIID: 1916812
• Length: 1527
• Species: Mus musculus
• Alignment Length: 1092
• Identity: 430/1092 - (39%)
• Similarity: 560/1092 - (51%)
• Gaps: 229/1092 - (20%)

  Fly   131 EMKRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAPSKSNER 195
            |:||..|.|          ::...::|::|.                        |.|..::.:|
Mouse    88 EVKRLARGK----------RRPGGRQKRRRG------------------------PRAGQEAEKR 118

  Fly   196 TVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSN-----YYGESSLETANSALGSNLQVTVTNKQ 255
            .|.:.|..........||.....|.|...:.:|.     ..|.:|..||.:|.|.    |..|..
Mouse   119 RVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGG----TGGNGG 179

  Fly   256 SISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGG-----------GVGSGSVVRDSRSS 309
            |         |:| |||...|...|.|.|.....||||..           |..|||....:| |
Mouse   180 S---------PAS-SSGTQRRAEGSERRPRRDRRSSSGRSKERHREHRRRDGTRSGSEASKAR-S 233

  Fly   310 RYVNSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDR---------------- 358
            |:.:|..:...:|...||...|.:.:.:.|.|||..:||.:.|.....|
Mouse   234 RHGHSGEERAEAAKSGSSSSSGGRRKSASATSSSSSSRKDRDLKAHRSRTKSSKEPPSAYKEPPK 298

  Fly   359 -YNHQPSTPPHKRRKFSDGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPS 422
             |....|.|...||:......:| |..|....|        |...|.||.:||         ||:
Mouse   299 AYREDKSEPKAYRRRQRSLSPLG-GRDESPVSH--------RASQSLRSRKSP---------SPA 345

  Fly   423 GGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTR----TSKRASGTGTSGDRYSRSPRTSSRYMES 483
            ||.||             .|...:..:||..:|    :..|.|.....|| .|.||.:||.:..|
Mouse   346 GGGSS-------------PYSRRLPRSPSPYSRRRSPSYSRHSSYERGGD-VSPSPYSSSSWRRS 396

  Fly   484 -SPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRSR----SPTSRDLKHKRE 543
             ||.|||         .|||.:.|.|:...| |.|.|.:....|.||||    ||::..||
Mouse   397 RSPYSPV---------LRRSAKSRSRSPYSS-RHSRSRSRHRLSRSRSRHSSISPSTLTLK---- 447

  Fly   544 EYIKKISETSLFAELVKDRHKR----QKALKEIIERQEENSNSNSNGALTINDNSSSVDGNTPNA 604
                    :||.|||.|::..|    .:|.:.....:...:...:..|...::.|:...|||...
Mouse   448 --------SSLAAELNKNKKARAAEAARAAEAAKAAEAAKAAEAAAKAAKASNASTPTKGNTETG 504

  Fly   605 AD------GRSAPGSGTPAAASTTSNGL---QALGSKPDLDL----NNIPMPNKQNDSVV---SN 653
            |.      .:......|..|.|.:|.|.   ....:||.|.:    ||:.:......:||   |.
Mouse   505 ASVSQTNHVKEVKKLKTEHAPSPSSGGTVKSDKAKTKPPLQVTKVDNNLTVEKATKKTVVGKESK 569

  Fly   654 PASNADVPDSVAQLKQPLLVPPFSASKNN-----IKPKSLTSLPLPPGMNVLDLAGARSPSPGQK 713
            ||:..:.|.|..:..:||  .|.:.:|..     :...:|..|||||.:             .:.
Mouse   570 PAATKEEPVSTKEKSKPL--TPSTGAKEKEQHVALVTSTLPPLPLPPML-------------PED 619

  Fly   714 KESDEKNVTSSGSANKS---------VLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHG 769
            |::|......|..|.|.         :.:||:||.:||.::||      .|||:....|  .:|
Mouse   620 KDADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLS------KSPEEKKTAA--QLH- 675

  Fly   770 HGGGPGTTRQRPVILNRR--DSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVAL 832
                   :::||.|...|  :.:....|||:||||.|::|..||||||||||||||..|.:||||
Mouse   676 -------SKRRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVAL 733

  Fly   833 KKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDL 897
            |||||::|||||||||:|||||||||.|::|:|:.||||||:||::|:||||:||||||||||||
Mouse   734 KKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDL 798

  Fly   898 MGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYN 962
            |||||||:|.|||.:..|.|:||::||:||||||||||||||||||:||||::|||||||||||:
Mouse   799 MGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYS 863

  Fly   963 ADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETIS 1027
            ::: .||||||||||||||||||||||||.|:||||||||||||||.|:|:||||.|:||||.||
Mouse   864 SEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELIS 927

  Fly  1028 KICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDA 1092
            :|||||.|||||:|||||.|:|:|.||.:||:|||:|.|:||.||||.|.||.|||.||.|||.|
Mouse   928 RICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQA 992

  Fly  1093 LRSPWLRKINPDEMPTPQ----------------LPTWQDCHELWSKKRRRQ 1128
            |:..:||.:.|.:||.|:                ||.|||||||||||||||
Mouse   993 LQCEFLRDVEPSKMPPPERFLHAEAMHHSKMAESLPLWQDCHELWSKKRRRQ 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	226/301 (75%)
Cdk13	XP_006516829.1	STKc_CDK12	697..998	CDD:270847	226/301 (75%)