DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk12 and Cdk13

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	XP_006516829.1	Gene:	Cdk13 / 69562	MGIID:	1916812	Length:	1527	Species:	Mus musculus

Alignment Length:	1092	Identity:	430/1092 - (39%)
Similarity:	560/1092 - (51%)	Gaps:	229/1092 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 EMKRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAPSKSNER 195
            |:||..|.|          ::...::|::|.                        |.|..::.:|
Mouse    88 EVKRLARGK----------RRPGGRQKRRRG------------------------PRAGQEAEKR 118

  Fly   196 TVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSN-----YYGESSLETANSALGSNLQVTVTNKQ 255
            .|.:.|..........||.....|.|...:.:|.     ..|.:|..||.:|.|.    |..|..
Mouse   119 RVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGG----TGGNGG 179

  Fly   256 SISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGG-----------GVGSGSVVRDSRSS 309
            |         |:| |||...|...|.|.|.....||||..           |..|||....:| |
Mouse   180 S---------PAS-SSGTQRRAEGSERRPRRDRRSSSGRSKERHREHRRRDGTRSGSEASKAR-S 233

  Fly   310 RYVNSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDR---------------- 358
            |:.:|..:...:|...||...|.:.:.:.|.|||..:||.:.|.....|
Mouse   234 RHGHSGEERAEAAKSGSSSSSGGRRKSASATSSSSSSRKDRDLKAHRSRTKSSKEPPSAYKEPPK 298

  Fly   359 -YNHQPSTPPHKRRKFSDGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPS 422
             |....|.|...||:......:| |..|....|        |...|.||.:||         ||:
Mouse   299 AYREDKSEPKAYRRRQRSLSPLG-GRDESPVSH--------RASQSLRSRKSP---------SPA 345

  Fly   423 GGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTR----TSKRASGTGTSGDRYSRSPRTSSRYMES 483
            ||.||             .|...:..:||..:|    :..|.|.....|| .|.||.:||.:..|
Mouse   346 GGGSS-------------PYSRRLPRSPSPYSRRRSPSYSRHSSYERGGD-VSPSPYSSSSWRRS 396

  Fly   484 -SPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRSR----SPTSRDLKHKRE 543
             ||.|||         .|||.:.|.|:...| |.|.|.:....|.||||    ||::..||
Mouse   397 RSPYSPV---------LRRSAKSRSRSPYSS-RHSRSRSRHRLSRSRSRHSSISPSTLTLK---- 447

  Fly   544 EYIKKISETSLFAELVKDRHKR----QKALKEIIERQEENSNSNSNGALTINDNSSSVDGNTPNA 604
                    :||.|||.|::..|    .:|.:.....:...:...:..|...::.|:...|||...
Mouse   448 --------SSLAAELNKNKKARAAEAARAAEAAKAAEAAKAAEAAAKAAKASNASTPTKGNTETG 504

  Fly   605 AD------GRSAPGSGTPAAASTTSNGL---QALGSKPDLDL----NNIPMPNKQNDSVV---SN 653
            |.      .:......|..|.|.:|.|.   ....:||.|.:    ||:.:......:||   |.
Mouse   505 ASVSQTNHVKEVKKLKTEHAPSPSSGGTVKSDKAKTKPPLQVTKVDNNLTVEKATKKTVVGKESK 569

  Fly   654 PASNADVPDSVAQLKQPLLVPPFSASKNN-----IKPKSLTSLPLPPGMNVLDLAGARSPSPGQK 713
            ||:..:.|.|..:..:||  .|.:.:|..     :...:|..|||||.:             .:.
Mouse   570 PAATKEEPVSTKEKSKPL--TPSTGAKEKEQHVALVTSTLPPLPLPPML-------------PED 619

  Fly   714 KESDEKNVTSSGSANKS---------VLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHG 769
            |::|......|..|.|.         :.:||:||.:||.::||      .|||:....|  .:|
Mouse   620 KDADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLS------KSPEEKKTAA--QLH- 675

  Fly   770 HGGGPGTTRQRPVILNRR--DSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVAL 832
                   :::||.|...|  :.:....|||:||||.|::|..||||||||||||||..|.:||||
Mouse   676 -------SKRRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVAL 733

  Fly   833 KKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDL 897
            |||||::|||||||||:|||||||||.|::|:|:.||||||:||::|:||||:||||||||||||
Mouse   734 KKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDL 798

  Fly   898 MGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYN 962
            |||||||:|.|||.:..|.|:||::||:||||||||||||||||||:||||::|||||||||||:
Mouse   799 MGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYS 863

  Fly   963 ADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETIS 1027
            ::: .||||||||||||||||||||||||.|:||||||||||||||.|:|:||||.|:||||.||
Mouse   864 SEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELIS 927

  Fly  1028 KICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDA 1092
            :|||||.|||||:|||||.|:|:|.||.:||:|||:|.|:||.||||.|.||.|||.||.|||.|
Mouse   928 RICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQA 992

  Fly  1093 LRSPWLRKINPDEMPTPQ----------------LPTWQDCHELWSKKRRRQ 1128
            |:..:||.:.|.:||.|:                ||.|||||||||||||||
Mouse   993 LQCEFLRDVEPSKMPPPERFLHAEAMHHSKMAESLPLWQDCHELWSKKRRRQ 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	226/301 (75%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	220/293 (75%)
Cdk13	XP_006516829.1	STKc_CDK12	697..998	CDD:270847	226/301 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845498
Domainoid	1	1.000	463	1.000	Domainoid score	I473
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	602	1.000	Inparanoid score	I938
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		otm42978
orthoMCL	1	0.900	-	-		OOG6_101677
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790