DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk12 and Cdk12

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001103096.1	Gene:	Cdk12 / 69131	MGIID:	1098802	Length:	1484	Species:	Mus musculus

Alignment Length:	1196	Identity:	437/1196 - (36%)
Similarity:	603/1196 - (50%)	Gaps:	248/1196 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVEYSDVSSED--FSDQEAGDLDADAGKGAGNIKKPKPAPDNQFSKGRLDAKPDKEGYDNYRSRR 73
            ||||.|:||:.  |||..|...|               ..:|:..:| .|.......:.:::.||
Mouse    70 LVEYDDISSDSDTFSDDTAFKSD---------------RRENEERRG-TDRSDRLHRHRHHQHRR 118

  Fly    74 AEDSSDPVAAGSRQT---SSSEATNPREEPSQASNTSKDELWGREIY---MSSDSIDTDELEAEM 132
            :.|     ...::||   .:.|.:.......:.|.:||..:.|.:.|   ..|.|...:...::|
Mouse   119 SRD-----LLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDYGKAQLSKSGSKESRSSKM 178

  Fly   133 KRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAPSKSNERTV 197
            .::|.:|:::.|..:|.:.|| .||::..|||.::.|                |...|:|..|..
Mouse   179 HKEKTRKERELKSGYKDRSKS-HRKRETPKSYKTVAS----------------PKRRSRSPHRKW 226

  Fly   198 SAAPSSFTPHNLKESSSPA----------TPPPVRRPNTNSNYYGESSLETANSALGSNLQVTVT 252
            |        .:.|:..||:          :||   |.:|:|||      ::...:.||     .:
Mouse   227 S--------DSSKQDDSPSGASYGQDYDLSPP---RSHTSSNY------DSYKKSPGS-----TS 269

  Fly   253 NKQSISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSRSSRYVNSPHK 317
            .:||||      ||....|.    :.:|.|:|.|.                  ||..|.|:...:
Mouse   270 RRQSIS------PPYKEPSA----YQSSTRSPSPY------------------SRRQRSVSPYSR 306

  Fly   318 EDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVGLG 382
            ...|::.||       |.|||...|.:..|:..  ||.|.:.:...|..|.::...|..|.....
Mouse   307 RRSSSYERS-------GSYSGRSPSPYGRRRSS--SPFLSKRSLSRSPLPSRKSMKSRSRSPAYS 362

  Fly   383 NFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHKHKYGTTVS 447
              .||..||.|....||   ||.||.||.       :.|..                       |
Mouse   363 --RHSSSHSKKKRSGSR---SRHSSISPV-------RLPLN-----------------------S 392

  Fly   448 STPSHTTRTSKRASGTGTSGDRYSRSPRTSSRYMESSP---PSPVGASGSHHYHHRRSPRMRQRT 509
            |..:..:|..|..:....:.       :...:..:|||   |              :..::..:.
Mouse   393 SLGAELSRKKKERAAAAAAA-------KMDGKESKSSPIILP--------------KKEKLEVKE 436

  Fly   510 RGDSRRRSPSSASSESSASRSRSPT----SRDLKH-------KREEYIKKISETSLFAELVKDRH 563
            .|...::.|.|..||.|...:...|    :.::||       :.:|.::|.....|.|:..||
Mouse   437 SGLESKKLPRSIKSEKSTPDTELVTVAHSNPEVKHCLDTGKVRLDENLQKHPAKDLKAQGTKD-- 499

  Fly   564 KRQKALKEII--ERQEENSNSNSNGALTINDNSSSVDGNTPNAADGRSAPGSGTPAAASTTSNGL 626
            .:..|.||:|  .::.|.|...:...|....:...:...||........|....||..      |
Mouse   500 VKPVAPKEVIVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIP------L 558

  Fly   627 QALGSKPDLDLNNIPM---------PNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNN 682
            |.....|....:.:|:         |:.:..::.|.  :|:..|..|:...|..:    :|:..:
Mouse   559 QPPLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQ--TNSQPPVQVSMKTQVSI----TAAIPH 617

  Fly   683 IKPKSLTSLPLP---PGMNVLDLAGARSPSPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPGSE 744
            :|..:|..||||   ||.:.:|......||...|||.:::       ....:.:||:||.:||
Mouse   618 LKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPAKKEKEQR-------TRHLLTDLPLPPELPG-- 673

  Fly   745 ELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTT--RQRPVILNRR--DSRNNVRDWGERCVDVFE 805
               ||....||||    |...|       |...  ::||.|...|  :.|....|||:||||.|:
Mouse   674 ---GDPSPPDSPE----PKAIT-------PPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFD 724

  Fly   806 MIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIV 870
            :|..||||||||||||:|..|.::||||||||::|||||||||:|||||||||.|:::||:.|||
Mouse   725 IIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIV 789

  Fly   871 TDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHR 935
            ||||||::|:||||:|||||||||||||||||||:|.|:|::..|.||||::||:||||||||||
Mouse   790 TDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHR 854

  Fly   936 DIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSC 1000
            ||||||||:||.|::||||||||||||::: .||||||||||||||||||||||||.|:||||||
Mouse   855 DIKCSNILLNNSGQIKLADFGLARLYNSEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 918

  Fly  1001 GCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFE 1065
            ||||||||.|:|:||||.|:||||.||::||||.|||||:|||||.|:|:|.||.:||||||:|.
Mouse   919 GCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFS 983

  Fly  1066 FMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMR 1130
            |:|:.||||||.||.|||.||.|||..|:|.:|:.:...:|..|.||.|||||||||||||||
Mouse   984 FIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQ-- 1046

  Fly  1131 EQQESL----PPTVIASTKYQQHGAT 1152
             :|..:    ||...||.|....|.|
Mouse  1047 -RQSGIVIEDPPPSKASRKETTSGTT 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	225/301 (75%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	219/293 (75%)
Cdk12	NP_001103096.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..465		98/412 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..699		38/231 (16%)
		STKc_CDK12	715..1016	CDD:270847	160/307 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1101		44/56 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1199		23/46 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1219..1363
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	463	1.000	Domainoid score	I473
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	602	1.000	Inparanoid score	I938
Isobase	1	0.950	-	0	Normalized mean entropy	S1668
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		otm42978
orthoMCL	1	0.900	-	-		OOG6_101677
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.900