DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdk12 and CDK17

DIOPT Version :10

Sequence 1:NP_649325.2 Gene:Cdk12 / 40385 FlyBaseID:FBgn0037093 Length:1157 Species:Drosophila melanogaster
Sequence 2:NP_002586.2 Gene:CDK17 / 5128 HGNCID:8750 Length:523 Species:Homo sapiens


Alignment Length:515 Identity:161/515 - (31%)
Similarity:248/515 - (48%) Gaps:73/515 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   615 TPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSN--PASNADVPDSVAQLKQPLLVPPFS 677
            |...:.|....|..|..:..::.|:    :|.|:.:|.|  |.::..:...:.|.......||..
Human    11 TLRGSQTIDESLSELAEQMTIEENS----SKDNEPIVKNGRPPTSHSMHSFLHQYTGSFKKPPLR 71

  Fly   678 ASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTSSGSA--------------- 727
            ...:.|.....:.:.:|...:.||:. ..:...|...|||:.:.|||...               
Human    72 RPHSVIGGSLGSFMAMPRNGSRLDIV-HENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRR 135

  Fly   728 ------NKSVLNLPMPPVIPGS--EELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVIL 784
                  ||. |:||....||..  |:|.     |:|| .||.|                     :
Human   136 ISMEDLNKR-LSLPADIRIPDGYLEKLQ-----INSP-PFDQP---------------------M 172

  Fly   785 NRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAV 849
            :||..|.::.:.|...::.:..:.::|||||..|||.|...|.::||||::||||| ||.|.||:
Human   173 SRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAI 236

  Fly   850 REIKILRQLNHRNIVNLHEIV-TDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENN 913
            ||:.:|:.|.|.|||.||:|| |||           |..|||||:|.||...::......:..|.
Human   237 REVSLLKDLKHANIVTLHDIVHTDK-----------SLTLVFEYLDKDLKQYMDDCGNIMSMHNV 290

  Fly   914 ASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLW 978
            ...:.|:|.||.|||::..||||:|..|:|:|.:|::|||||||||..:..  .:.|:|:|:|||
Human   291 KLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVP--TKTYSNEVVTLW 353

  Fly   979 YRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIK 1043
            ||||::|||...|...||:|..|||..|:...||||..:....:|..|.::.|:|....||.:..
Human   354 YRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISS 418

  Fly  1044 LPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINP 1103
            ...|......|...:.|......:.:..::|:.|.|..:..||::||:|::..:.|.:.|
Human   419 NEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdk12NP_649325.2 STKc_CDK12 796..1098 CDD:270847 117/302 (39%)
CDK17NP_002586.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..55 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..123 7/19 (37%)
STKc_PCTAIRE2 185..493 CDD:143377 119/308 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..523
Blue background indicates that the domain is not in the aligned region.

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