Protein Alignment Cdk12 and CDK16

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_011542222.1
• Gene: CDK16 / 5127
• HGNCID: 8749
• Length: 571
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 190/629 - (30%)
• Similarity: 277/629 - (44%)
• Gaps: 148/629 - (23%)

  Fly   546 IKKISETSLFAELVKDRHKRQKALKEIIERQEENSNSNSNGALTIN--------DNSSSVDGNTP 602
            :..||..:|..::..||.|:       |:||...:.....|....|        |.|....|:.|
Human    61 LPSISHLNLRTQIAMDRMKK-------IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDP 118

  Fly   603 NAADGRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQL 667
            ..|..|:|||....|..        .|.|.|::...::.|.:.......|  |:::|      ::
Human   119 GEAPTRAAPGELRSARG--------PLSSAPEIVHEDLKMGSDGESDQAS--ATSSD------EV 167

  Fly   668 KQPLLV-----PPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTSSGSA 727
            :.|:.|     ||...|..:|..:    |.||        |..|.|               .|..
Human   168 QSPVRVRMRNHPPRKISTEDINKR----LSLP--------ADIRLP---------------EGYL 205

  Fly   728 NKSVLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNN 792
            .|..||.|:                      ||.|                     |:||..|.:
Human   206 EKLTLNSPI----------------------FDKP---------------------LSRRLRRVS 227

  Fly   793 VRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQ 857
            :.:.|...::.:..:.::|||||..|||.:...|:::||||::||||| ||.|.||:||:.:|:.
Human   228 LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKD 291

  Fly   858 LNHRNIVNLHEIV-TDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLL 921
            |.|.|||.||:|: |:|           |..|||||:|.||...|:......|..|....:.|||
Human   292 LKHANIVTLHDIIHTEK-----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 345

  Fly   922 DGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLL 986
            .||.|||::..||||:|..|:|:|.||::|||||||||..:..  .:.|:|:|:|||||||::||
Human   346 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIP--TKTYSNEVVTLWYRPPDILL 408

  Fly   987 GEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLK 1051
            |...|...||:|..|||..|:...||||..:....||..|.:|.|:|....||.::....|.|..
Human   409 GSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 473

  Fly  1052 QKK-------THRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTP 1109
            ..|       :|..||..|       ..|||.|:|..:...||:||||::.|:...:.......|
Human   474 YPKYRAEALLSHAPRLDSD-------GADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLP 531

  Fly  1110 QLPTWQDCHELWSKKRRRQMRE---QQESLPPTVIASTKYQQHG 1150
                  |...:::.|..:..:|   :..|:|.:|...    |||
Human   532 ------DTTSIFALKEIQLQKEASLRSSSMPDSVAGG----QHG 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	128/309 (41%)
CDK16	XP_011542222.1	STKc_PCTAIRE1	236..532	CDD:270854	128/322 (40%)