Protein Alignment Cdk12 and cdk11b

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_009302607.1
• Gene: cdk11b / 494103
• ZFINID: ZDB-GENE-041212-74
• Length: 807
• Species: Danio rerio
• Alignment Length: 913
• Identity: 245/913 - (26%)
• Similarity: 369/913 - (40%)
• Gaps: 225/913 - (24%)

  Fly   303 VRDSRSSRYV-NSPH-KEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPST 365
            :||.|....: |||: :||      |:.|.|.:............|||.|       .|:.:...
Zfish    53 LRDHRMEITIRNSPYTRED------STEDRGEEDESLAIKPPQQMTRKDK-------NYHRKEEK 104

  Fly   366 PPHKRRKFSDGREVGLGNFEHSRHHSGKYER-------------YSRDRYSRRSSRSPSVQHSRS 417
            ...|||:.|...|   |..:|.|....:.||             .:|..|.|:..|..:..|||
Zfish   105 RKDKRRRRSHSAE---GAEKHPRTKDKEKERENERRKRQWHEDNKARQDYERQKRRDQARAHSR- 165

  Fly   418 RQSPSGGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRYME 482
                                                    :..|.|.|..||..:..|...|..:
Zfish   166 ----------------------------------------RERSDTLTQRDRLEQLERKRERDRK 190

  Fly   483 SSPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRSRSPTSRD--LKHKR--- 542
            .                |...:..||...:..||        :...|....|.||  :.|.|
Zfish   191 L----------------REQEQREQRELEERERR--------AKERRKDRDTRRDVPISHHRVAP 231

  Fly   543 -EEYIKKISETSLFAELVKDRHKRQKALKEIIERQEENSNSNSNGALTINDNSSSVD--GNTPNA 604
             |||..|       |.|   ||:.:...:..:..|.|....:|.....:.:.....|  .:..:.
Zfish   232 AEEYTDK-------ARL---RHRSRSRSRSPVRLQRETKAESSEPRRAVREGKVDKDPLSDLQDI 286

  Fly   605 ADGR---SAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQ 666
            :|..   |:|||...:.:          ||:.:.|        :.|:...|:..:..|....
Zfish   287 SDSERKTSSPGSSLGSGS----------GSEAEED--------EDNEEEESSSQTEGDEEGE--- 330

  Fly   667 LKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARS---PSPGQKKESDEKNVTSSGSAN 728
                      |.|::.....|               .||.|   ||. :::|.:|:....:|:
Zfish   331 ----------SGSESEGSEHS---------------GGALSDEEPSE-EEEEGEEEEERENGN-- 367

  Fly   729 KSVLNLPMPPVIPGS-----EELSGDDDVIDSPEDFDAPAVG-TVHGHGGGPGTTRQR------- 780
                  .:||| |.|     .|:|.:::..:..|..:..||. |...|  .|..|.:.
Zfish   368 ------HIPPV-PESRFDHDSEVSAEEEEEEEEEVEEEEAVDVTPQSH--APSATPEERYIPESP 423

  Fly   781 ---PVILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKE 842
               ||.|.:...:......|.|.|:.|:.:.:|.|||||.||:|:|..|:::||||::::|.|||
Zfish   424 PVSPVELKKELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE 488

  Fly   843 GFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVD 907
            |||||::|||..:.:..|.|||.:.|||      |....||  .|:|..|::|||..|:|:....
Zfish   489 GFPITSLREINTILKAQHPNIVTVREIV------VGSNMDK--IYIVMNYVEHDLKSLMETMKQP 545

  Fly   908 FNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTN 972
            |......::|.|||.|:.:.|....||||:|.||:|::::|.:|:.||||||.|.:.  .:|||.
Zfish   546 FLPGEVKTLMIQLLRGVRHLHDNWILHRDLKTSNLLLSHKGILKIGDFGLAREYGSP--LKPYTP 608

  Fly   973 KVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAV 1037
            .|:|||||.|:||||.:.|..::|:||.|||.|||..::|||...:|:.|:..|.|..|||...:
Zfish   609 VVVTLWYRSPDLLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKIFKDLGSPSEKI 673

  Fly  1038 WPNVIKLPLFHTLKQKKTHRRRLREDF-EFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKI 1101
            ||...:||....:...:.....||:.| ..:.....||::|.|...|.|||:|::||:..:.|
Zfish   674 WPGYSELPAVKKMTFTEYPYNNLRKRFGALLSDQGFDLMNKFLTYCPAKRISADEALKHEYFR-- 736

  Fly  1102 NPDEMPTP----QLPTWQDCHELWSKKRRRQMREQQ----------ESLPPTVIASTKYQQHGAT 1152
               |.|.|    ..|||....|....||....|..:          :.|..|....|...: ||:
Zfish   737 ---ESPLPIDPSMFPTWPAKSEQQRVKRGTSPRAPEGGQDFSQLGDDDLKDTGFHLTTANK-GAS 797

  Fly  1153 MVG 1155
            |.|
Zfish   798 MAG 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	125/302 (41%)
cdk11b	XP_009302607.1	STKc_CDC2L1	444..735	CDD:173741	124/300 (41%)