Protein Alignment Cdk12 and cdk2

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_998571.1
• Gene: cdk2 / 406715
• ZFINID: ZDB-GENE-040426-2741
• Length: 298
• Species: Danio rerio
• Alignment Length: 316
• Identity: 129/316 - (40%)
• Similarity: 191/316 - (60%)
• Gaps: 25/316 - (7%)

  Fly   801 VDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVN 865
            ::.|:.:.:|||||||.||||::..|.:.|||||:||:.|.||.|.||:|||.:|::|||.|||.
Zfish     1 MESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65

  Fly   866 LHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVD-FNEENNASIMKQLLDGLNYCHK 929
            |.:::          ..:...|||||::..||...::|..|. .:.....|.:.|||.||.:||.
Zfish    66 LRDVI----------HTENKLYLVFEFLHQDLKRFMDSTSVSGISLPLVKSYLFQLLQGLAFCHS 120

  Fly   930 KNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPS 994
            ...||||:|..|:|:|.:|::|||||||||.:...  .|.||::|:|||||.||:|||.:.|..:
Zfish   121 HRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVP--VRTYTHEVVTLWYRAPEILLGCKYYSTA 183

  Fly   995 IDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRR 1059
            :|:||.|||..|:..:|.||..::|:.||..|.:..|:|..::||.|..:|.:     |.:..:.
Zfish   184 VDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDESIWPGVTSMPDY-----KPSFPKW 243

  Fly  1060 LREDFEFMPAP----ALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQL 1111
            .|:|...:..|    ..|||.:||..||:|||:|::||...:.|.:.   ||.|.|
Zfish   244 ARQDLSKVVPPLDEDGRDLLGQMLTYDPNKRISAKNALVHRFFRDVT---MPVPPL 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	124/301 (41%)
cdk2	NP_998571.1	STKc_CDK2_3	3..286	CDD:270844	124/299 (41%)