DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk12 and Pitslre

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	965	Identity:	252/965 - (26%)
Similarity:	406/965 - (42%)	Gaps:	187/965 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 PPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSRSSRYVNSPHKEDVSAHHRSSH 328
            ||.:||.||:|||......:.....:......|..:.::.||          |:.|..:  |..|
  Fly    40 PPQASRESGSGPRREKKKHSRERRRHKERDDVGGAALALERD----------HRYDYRS--REEH 92

  Fly   329 DHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVGLGNFEHSRH---- 389
            .|.:|...|...::::       ....|....|.|..|..:::...........::.|.:|
  Fly    93 YHHHQRERSSNAAAAY-------AKHHLGHAYHYPQPPQQQQQPLPPAPSYAAHHYHHHQHLSGA 150

  Fly   390 --------------HSG-KYERYSRDRYSRRSSRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHK 439
                          ||| ::..|..:..:||||:   ...|:..:|....|.|.....||  ::.
  Fly   151 RAAPREYHSYPSGYHSGSRHGDYPMEEPTRRSSK---YAESKDAESLEQDLRSRLLKKRH--NYV 210

  Fly   440 HKYGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRY-----MESSPPSPVGASGSHHYHH 499
            ..|.|  .....|....|.|..|.....:|..||....:|:     :..||...     .||.|.
  Fly   211 KDYET--EENYEHRVERSDRREGGRKERERTVRSTHKQNRHDRVIELLDSPEQE-----HHHQHQ 268

  Fly   500 RRSPRMRQRTRGD-SRRRSPSSAS---------SESSASRSRSPTS-------RDLKHKREEYIK 547
            .:|.|.:.|...: .||:.|....         :....||.|..|:       |:|..:|.|:..
  Fly   269 HKSHRSKWREEVEVIRRKVPEDLELLARREKLLAAERESRQRKQTAREELEARRELLRERNEHSD 333

  Fly   548 KISETSLFAEL-------VKDRHKRQKALKEI-IERQEENSNSNSNGALTINDNSSSVDGNTPNA 604
            .:|.|::.|.:       ||.:.|.....||| ::::.|:...    .:..:|:..|.:.::...
  Fly   334 ALSPTTVAASVTAGLNIHVKRKSKPDNYEKEIKLKKRREDDIE----VIRDDDDEESEESDSNEE 394

  Fly   605 ADGRSAPGSGTPAAA--STTSNGLQALGSKPDL--DLNNIPMPNKQNDSVVSNPASNADVPDSVA 665
            ...:.:.||.|.:.:  |..|.....:.||..|  |..::|:|:        :|.|..::..|..
  Fly   395 VPEQDSEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPD--------SPLSVGELYKSPK 451

  Fly   666 QLKQPLLVPPFSASKNN----IKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKES--------DE 718
            |.::...|...|:|:::    .:.:|.:...|...::..|:....|||...:.|.        :|
  Fly   452 QRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEERGMTQEQPEE 516

  Fly   719 KNVTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVI 783
            |.........||:           .|::..||..|..|..:              ||..
  Fly   517 KPEEKLKEKQKSL-----------EEQIPCDDKGIPLPNYY--------------PGVQ------ 550

  Fly   784 LNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITA 848
                         |.|.|:.|:.:.:|.|||||.||:|:|..||::||||::::|.||||||||:
  Fly   551 -------------GCRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITS 602

  Fly   849 VREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLE---SGMVDFNE 910
            :|||..|.:..|.|||.:.|||      |....||  .::|.:|::|||..|:|   :....|..
  Fly   603 LREINTLLKGQHPNIVTVREIV------VGSNMDK--IFIVMDYVEHDLKSLMETMKNRKQSFFP 659

  Fly   911 ENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVI 975
            .....:.:|||..:.:.|....||||:|.||:|::::|.:|:.||||||.|.:..::  ||:.|:
  Fly   660 GEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKK--YTSLVV 722

  Fly   976 TLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPN 1040
            |||||.|||||....|...|||||.|||..|.....|||...:|:.:|..|.|..|:|...:||.
  Fly   723 TLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPG 787

  Fly  1041 VIKLPLFHTLKQKKTH-----RRRLREDF-EFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLR 1099
            ..:||....:..:.:.     ..:||:.| |......|.||..:|..||.:|::|:.||:..:.:
  Fly   788 YTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFK 852

  Fly  1100 KINPDEMPTP----QLPTWQDCHELWSKKRRRQMREQQESLPPTVIASTKYQQHG 1150
                 |:|.|    ..|||....||.::|       .|.|.|......::::|.|
  Fly   853 -----ELPLPIDPSMFPTWPAKSELGARK-------AQASSPKPPSGGSQFKQLG 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	122/310 (39%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	119/302 (39%)
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	121/308 (39%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	120/313 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	56	1.000	Inparanoid score	I1799
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.000