Protein Alignment Cdk12 and Cdk8

DIOPT Version :9

• Sequence 1: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Alignment Length: 387
• Identity: 125/387 - (32%)
• Similarity: 190/387 - (49%)
• Gaps: 92/387 - (23%)

  Fly   809 QIGEGTYGQVYKARDHHTND--MVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVT 871
            ::|.||||.||||:...|:|  ..|||::    :..|..::|.|||.:||:|.|:|::.|..:..
  Fly    26 KVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLRELKHQNVITLIRVFL 86

  Fly   872 DKQDAVEFRKDKGSFYLVFEYMDHDLMGLLE---------------SGMVDFNEENNASIMKQLL 921
            ...|    ||    .:|:.:|.:|||..:::               .|||       .|::.|:|
  Fly    87 SHND----RK----VFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMV-------KSLLYQIL 136

  Fly   922 DGLNYCHKKNFLHRDIKCSNILM----NNRGKVKLADFGLARLYNADDRERPYTN---KVITLWY 979
            ||::|.|....||||:|.:|||:    |.||:||:||.|.|||:||.  .:|..:   .|:|.||
  Fly   137 DGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAP--LKPLADLDPVVVTFWY 199

  Fly   980 RPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAE---------MAQLETISKICGSPVP 1035
            |.||||||...|..:||:|:.|||..||....|:|....|         ..||:.|..:.|.|..
  Fly   200 RAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQD 264

  Fly  1036 AVWPNVIKLPLFHTLKQ-------------KKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRI 1087
            ..|.::.|:|..|||.:             |...|.:::.|     :.|..||.|:|.:||:|||
  Fly   265 KDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPD-----SKAFHLLQKLLLMDPNKRI 324

  Fly  1088 TAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSK---------------KRRRQMREQQE 1134
            |:|.|::..:.:     |.|.|....:..|...:.|               ||::|.::||:
  Fly   325 TSEQAMQDQYFQ-----EEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQ 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	115/334 (34%)
		S_TKc	804..1098	CDD:214567	115/334 (34%)
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	115/334 (34%)
		S_TKc	22..335	CDD:214567	115/334 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442415
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24056
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030