Protein Alignment Cdk12 and Cdk9

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001007744.1
• Gene: Cdk9 / 362110
• RGDID: 1359638
• Length: 372
• Species: Rattus norvegicus
• Alignment Length: 366
• Identity: 165/366 - (45%)
• Similarity: 232/366 - (63%)
• Gaps: 25/366 - (6%)

  Fly   800 CVDV--FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRN 862
            |.:|  :|.:|:||:||:|:|:||:...|...||||||.:|:|||||||||:||||||:.|.|.|
  Rat    13 CDEVTKYEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77

  Fly   863 IVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYC 927
            :|||.||...|  |..:.:.|||.||||::.:|||.|||.:.:|.|.......:|:.||:||.|.
  Rat    78 VVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140

  Fly   928 HKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERP--YTNKVITLWYRPPELLLGEER 990
            |:...||||:|.:|:|:...|.:|||||||||.::.....:|  |||:|:|||||||||||||..
  Rat   141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERD 205

  Fly   991 YGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKT 1055
            |||.||:|..|||:.|::.:.|:.|.|.|..||..||::|||..|.|||||.|..||..|:..|.
  Rat   206 YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKG 270

  Fly  1056 HRRRLREDFE-FMPAP-ALDLLDKMLDLDPDKRITAEDALRSP--WLRKINPDEMPTPQLPTWQD 1116
            .:|::::..: ::..| ||||:||:|.|||.:||.::|||...  |     .|.||: .|.....
  Rat   271 QKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW-----SDPMPS-DLKGMLS 329

  Fly  1117 CH-----ELWSKKRRR--QMREQ--QESLPPTVIASTKYQQ 1148
            .|     |..:..||:  |:.:|  .:|..|.....|::::
  Rat   330 THLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFER 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	151/305 (50%)
Cdk9	NP_001007744.1	STKc_CDK9	6..315	CDD:270848	151/303 (50%)
		T-loop. /evidence=ECO:0000250	166..191		12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372		7/28 (25%)