Protein Alignment Cdk12 and Cdk13

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_038951649.1
• Gene: Cdk13 / 306998
• RGDID: 1311226
• Length: 1527
• Species: Rattus norvegicus
• Alignment Length: 1098
• Identity: 430/1098 - (39%)
• Similarity: 556/1098 - (50%)
• Gaps: 241/1098 - (21%)

  Fly   131 EMKRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAPSKSNER 195
            |:||..|.|          ::...::|::|.                        |.|..::.:|
  Rat    88 EVKRLARGK----------RRPGGRQKRRRG------------------------PRAGQEAEKR 118

  Fly   196 TVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSN-----YYGESSLETANSALGSNLQVTVTNKQ 255
            .|.:.|..........||.....|.|...:.:|.     ..|.:|..||.:|.|.    |..|..
  Rat   119 RVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGG----TGGNGG 179

  Fly   256 SISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGG-----------GVGSGSVVRDSRSS 309
            |         |:| |||...|...|.|.|.....||||..           |..|||....:| |
  Rat   180 S---------PAS-SSGTQRRAEGSERRPRRDRRSSSGRSKERHREHRRRDGTRSGSEASKAR-S 233

  Fly   310 RYVNSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDR---------------- 358
            |:.:|..:...:|...||...|.:.:.:.|.|||..:||.:.|.....|
  Rat   234 RHGHSGEERAEAAKSGSSSSSGGRRKSASATSSSSSSRKDRDLKAHRSRTKSSKEPPSAYKEPPK 298

  Fly   359 -YNHQPSTPPHKRRKFSDGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPS 422
             |....|.|...||:......:| |..|....|        |...|.||.:||         ||:
  Rat   299 AYREDKSEPKAYRRRQRSLSPLG-GRDESPVSH--------RASQSLRSRKSP---------SPA 345

  Fly   423 GGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTR----TSKRASGTGTSGDRYSRSPRTSSRYMES 483
            ||.||             .|...:..:||..:|    :..|.|.....|| .|.||.:||.:..|
  Rat   346 GGGSS-------------PYSRRLPRSPSPYSRRRSPSYSRHSSYERGGD-VSPSPYSSSSWRRS 396

  Fly   484 -SPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRSR----SPTSRDLKHKRE 543
             ||.|||         .|||.:.|.|:...| |.|.|.:....|.||||    ||::..||
  Rat   397 RSPYSPV---------LRRSAKSRSRSPYSS-RHSRSRSRHRLSRSRSRHSSISPSTLTLK---- 447

  Fly   544 EYIKKISETSLFAELVKDRHKRQKALKEIIERQEENSNSNSNGALTINDNSSSVD----GNTPNA 604
                    :||.|||.|::..|........|..:....:.:..|......:|||.    |||...
  Rat   448 --------SSLAAELNKNKKARAAEAARAAEAAKAAEAAKAAEAAAKAAKASSVSTPTKGNTETG 504

  Fly   605 A----------------DGRSAPGSGTPAAASTTSNGLQALGSKPDLDL----NNIPMPNKQNDS 649
            |                :...:|.||....:..|.       :||.|.:    ||:.:......:
  Rat   505 ASVSQTNHVKEVKKLKTEHAPSPSSGGTVKSDKTK-------TKPPLQVTKVDNNLIVEKATKKT 562

  Fly   650 VV---SNPASNADVPDSVAQLKQPLLVPPFSASKNN----IKPKSLTSLPLPPGMNVLDLAGARS 707
            ||   |.||:..:.|.|..:..:| |.|...|.:..    :...:|..|||||.:
  Rat   563 VVGKESKPAATKEEPVSTKEKTKP-LTPSVGAKEKEQHVALVTSTLPPLPLPPML---------- 616

  Fly   708 PSPGQKKESDEKNVTSSGSANKS---------VLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPA 763
               .:.|::|......|..|.|.         :.:||:||.:||.::||      .|||  :...
  Rat   617 ---PEDKDADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLS------KSPE--EKKT 670

  Fly   764 VGTVHGHGGGPGTTRQRPVILNRR--DSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHT 826
            ...:|        :::||.|...|  :.:....|||:||||.|::|..||||||||||||||..|
  Rat   671 ATQLH--------SKRRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDT 727

  Fly   827 NDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFE 891
            .:|||||||||::|||||||||:|||||||||.|::|:|:.||||||:||::|:||||:||||||
  Rat   728 GEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFE 792

  Fly   892 YMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFG 956
            |||||||||||||:|.|||.:..|.|:||::||:||||||||||||||||||:||||::||||||
  Rat   793 YMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857

  Fly   957 LARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMA 1021
            |||||:::: .||||||||||||||||||||||||.|:||||||||||||||.|:|:||||.|:|
  Rat   858 LARLYSSEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELA 921

  Fly  1022 QLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKR 1086
            |||.||:|||||.|||||:|||||.|:|:|.||.:||:|||:|.|:||.||||.|.||.|||.||
  Rat   922 QLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKR 986

  Fly  1087 ITAEDALRSPWLRKINPDEMPTPQ----------------LPTWQDCHELWSKKRRRQ 1128
            .|||.||:..:||.:.|.:||.|:                ||.|||||||||||||||
  Rat   987 CTAEQALQCEFLRDVEPSKMPPPERFLHAEAMHHSKMAESLPLWQDCHELWSKKRRRQ 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	226/301 (75%)
Cdk13	XP_038951649.1	STKc_CDK12	697..998	CDD:270847	226/301 (75%)