Protein Alignment Cdk12 and Prpf4b

DIOPT Version :9

• Sequence 1: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001011923.1
• Gene: Prpf4b / 291078
• RGDID: 1307784
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 1156
• Identity: 274/1156 - (23%)
• Similarity: 419/1156 - (36%)
• Gaps: 301/1156 - (26%)

  Fly    93 ATNP---REEP--SQASNTSKDELWGREIYMSSDSIDTDELEAEMKRQKRK------KQKKEKH- 145
            ||.|   ||:|  ..|.|:.|      .:...:..:..|:.:.:..|.|:|      |.||.||
  Rat     3 ATEPPSLREQPEMDDADNSEK------SVNEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHS 61

  Fly   146 -------KHKSKKKSKKRKKKRAKSYSSIDSMSD------ND-------------INALLDRRYT 184
                   |||.|.|.||.|:|.....|..:.:|.      :|             |.|.||....
  Rat    62 SEEDRDKKHKHKHKHKKHKRKEVLDASDKEGLSPAKRTKLDDLALLEDLEKQRALIKAELDNELM 126

  Fly   185 PPTAPS---------------------KSNERTVSAAPSSFTPHNLKESSSPATPPPVRRPNTNS 228
            .....|                     |:.....|:..||.|...|:.:.:..:..  :|..:.|
  Rat   127 EGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTRGKLEITDNKNSAK--KRSKSRS 189

  Fly   229 NYYGESSLETANSALGSNLQVTVTNKQSISNRLRSPPPSSRS-SGNGPRFGNSP----------- 281
            ........:...|.....:.....|:.....|.:|..||.|| |.:..|...||
  Rat   190 KERTRHRSDKRKSKGAVEMMREKANRSKSKERRKSKSPSKRSKSQDQARKSKSPTLRRRSQEKVG 254

  Fly   282 --RTPPPSHYSSSGGGGVGSGSVVRDSRSSRYVNSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSH 344
              |:|......|...|      .::|.:.|..||. ...|.|...:|..|  .:.:.....|.|.
  Rat   255 KARSPADEKIKSEEKG------KIKDRKKSPIVNE-RSRDRSKKSKSPVD--LRDKSKDRRSRSK 310

  Fly   345 DTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVGLGNFEHSRHHSGKYERYS---RDRYSRRS 406
            : ||.||  .|:|: ..:|...|.|  ..|.|:|    |...||......:|.|   :.|...|.
  Rat   311 E-RKSKR--SEIDK-EKKPIKSPSK--DASSGKE----NRSPSRRPGRSPKRRSLSPKQRDKSRR 365

  Fly   407 SRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYS 471
            ||||.:...||:||.|                           ||.|....:||........|..
  Rat   366 SRSPLLNDRRSKQSKS---------------------------PSRTLSPGRRAKSRSLERKRRE 403

  Fly   472 ------RSPRTS------SRYMESSPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSS-ASS 523
                  .||||.      .|...|...||:         :|.|| .|:|:|...||||.|. ..|
  Rat   404 PERRRLSSPRTRPRDDILGRCERSKDASPI---------NRWSP-SRRRSRSPIRRRSRSPLRRS 458

  Fly   524 ESSASRSRSPTSRDLKHKREEYIKKISETSLFAELVKDRHKRQKALKEIIERQEENSNSNSNGAL 588
            .|...|||||..||...:....:::.|.:       :..|:|:...|   .::::...|.|.| :
  Rat   459 RSPRRRSRSPRRRDRSRRSRSRLRRRSRS-------RGGHRRRSRSK---VKEDKFKGSLSEG-M 512

  Fly   589 TINDNSSSVDGNTPNAADGRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSN 653
            .:...|||.|                                     :|.:..:..:..::|:..
  Rat   513 KVEQESSSDD-------------------------------------NLEDFDVEEEDEEAVIEQ 540

  Fly   654 PASNADVPDSVAQLKQPLLVPPFS--ASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSP------ 710
                       .::::..:|..:.  |..:||   |:.|.|..|..:    ..:|||||
  Rat   541 -----------RRIQRQAIVQKYKYLAEDSNI---SVPSEPSSPQSS----TRSRSPSPDDILER 587

  Fly   711 --GQKKESDEKNVTSSGSANKSVLNLPMPPVIPGSEE---LSGDDDVIDSPEDFDAPAVGTVHGH 770
              ...||.:.:||.:..::.|:..||.......||.:   |:  .|:....:|..|....:....
  Rat   588 VAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLA--PDMFTESDDMFAAYFDSARLR 650

  Fly   771 GGGPGTT-RQRPVILNRRDSRNNVRDW-----GERCVDVFEMIAQIGEGTYGQVYKARDH-HTND 828
            ..|.|.. ::.|   |.||:..:...:     ||.....:.:....|:|.:..|.:|||: ..|.
  Rat   651 AAGIGKDFKENP---NLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQ 712

  Fly   829 MVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFY------ 887
            .||:|.:|   ..|....|.::|::.|::||.          .|..|.....:....||
  Rat   713 EVAVKIIR---NNELMQKTGLKELEFLKKLND----------ADPDDKFHCLRLFRHFYHKQHLC 764

  Fly   888 LVFEYMDHDLMGLLESGMVDFNEENNA--SIMKQLLDGLNYCHKKNFLHRDIKCSNILMN-NRGK 949
            ||||.:..:|..:|:....|......|  |..:||...|....:.|.||.|||..|||:| ::..
  Rat   765 LVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTI 829

  Fly   950 VKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLF 1014
            :||.|||.|. :.||:...||   :::.:||.||:::|:. |...||:||.||.|.||:..:.||
  Rat   830 LKLCDFGSAS-HVADNDITPY---LVSRFYRAPEIIIGKS-YDYGIDMWSVGCTLYELYTGKILF 889

  Fly  1015 QANAEMAQLETISKICGS-PVPAVWPNVIK-------LPLFHTLKQKKTHR-------------- 1057
            ........|:....:.|. |...:...|.|       |...:....|.|.|
  Rat   890 PGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKD 954

  Fly  1058 --------RRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRK 1100
                    :||.||.........||||::|.|||.|||:...||:..::::
  Rat   955 LLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	98/346 (28%)
		S_TKc	804..1098	CDD:214567	96/333 (29%)
Prpf4b	NP_001011923.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104		29/106 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..535		108/499 (22%)
		PTZ00108	<171..396	CDD:240271	62/272 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..583		11/29 (38%)
		STKc_PRP4	686..1003	CDD:271037	96/334 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000