Protein Alignment Cdk12 and cdk9

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_595616.1
• Gene: cdk9 / 2540239
• PomBaseID: SPBC32H8.10
• Length: 591
• Species: Schizosaccharomyces pombe
• Alignment Length: 377
• Identity: 144/377 - (38%)
• Similarity: 210/377 - (55%)
• Gaps: 39/377 - (10%)

  Fly   786 RRDSRNNVRD--WGERCVDV--------------FEMIAQIGEGTYGQVYKARDHHTNDMVALKK 834
            :|.|..:|.|  ...|.:||              :.::.::||||:|:|||::......:.|||:
pombe     2 KRSSSVSVEDEKSARRKLDVVPKLHFVGCSHLTDYHLMEKLGEGTFGEVYKSQRRKDGKVYALKR 66

  Fly   835 VRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMG 899
            :.:..|||||||||:||||||:.:.|.||:.|.::...:.|....|  :||.|:|..||||||.|
pombe    67 ILMHTEKEGFPITAIREIKILKSIKHENIIPLSDMTVVRADKKHRR--RGSIYMVTPYMDHDLSG 129

  Fly   900 LLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNAD 964
            |||:..|.|.|......||||..|..|.|.:..||||:|.:|:|::|.|.:|:|||||||:...:
pombe   130 LLENPSVKFTEPQIKCYMKQLFAGTKYLHDQLILHRDLKAANLLIDNHGILKIADFGLARVITEE 194

  Fly   965 D-----------RERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANA 1018
            .           ..|.||..|:|.|||.|||||||.||..:||:||.|||:.|::..||:.|.::
pombe   195 SYANKNPGLPPPNRREYTGCVVTRWYRSPELLLGERRYTTAIDMWSVGCIMAEMYKGRPILQGSS 259

  Fly  1019 EMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDP 1083
            ::.||:.|.::||||..|..||..|||....::...:|.|.|...|.........|...:|.|:|
pombe   260 DLDQLDKIFRLCGSPTQATMPNWEKLPGCEGVRSFPSHPRTLETAFFTFGKEMTSLCGAILTLNP 324

  Fly  1084 DKRITAEDALRSPWLR----KINPDEMPTPQLPTWQDCHELWSKKRRRQMRE 1131
            |:|::|..||...:..    ..||.|     |.::...|| :.|:|:|:.|:
pombe   325 DERLSASMALEHEYFTTPPYPANPSE-----LQSYSASHE-YDKRRKREQRD 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	130/326 (40%)
cdk9	NP_595616.1	STKc_BUR1	27..339	CDD:270849	127/313 (41%)