DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk12 and Cdk11b

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_665709.2	Gene:	Cdk11b / 252879	RGDID:	628604	Length:	784	Species:	Rattus norvegicus

Alignment Length:	1067	Identity:	254/1067 - (23%)
Similarity:	388/1067 - (36%)	Gaps:	354/1067 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 DSIDTDELEAEMKRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTP 185
            ||.....|:..::.:||:|:::||.:.|..|.|..|..||       ||:.:.:   |.|.|.
  Rat     6 DSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR-------DSLEEGE---LRDHRM-- 58

  Fly   186 PTAPSKSNERTVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSNYYGESSLETANSALGSNLQVT 250
                    |.|:                            .||.|..|.|:|.
  Rat    59 --------EITI----------------------------RNSPYRREDSMED------------ 75

  Fly   251 VTNKQSISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSRSSRYVNSP 315
             ..::..|..::.|...||......| .:..|.....|.|.|..||          :.:|.....
  Rat    76 -RGEEDDSLAIKPPQQMSRKEKAHHR-KDEKRKEKRRHRSHSAEGG----------KHARVKEKE 128

  Fly   316 HKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVG 380
            .:.:....||...|                  |.:|   |.:|         .|||:.:.
  Rat   129 REHERRKRHREEQD------------------KARR---EWER---------QKRREMAR----- 158

  Fly   381 LGNFEHSRHHSGKYERYSRDRYSRRSSRSPS------------VQHSRSRQSPSGGLSSGSNAFR 433
                ||||....:.|:..|.|...|..|...            .:..|..:.....:|:.....|
  Rat   159 ----EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMR 219

  Fly   434 HGGSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRYMESSPPSPVGASGSHHYH 498
            ...|.|.|.|        |.:|:.             .|.||  .|:.......||
  Rat   220 EDYSDKGKVG--------HWSRSP-------------LRPPR--ERFELGDNRKPV--------- 252

  Fly   499 HRRSPRMRQRTR-------GDSRRRSPSSASSESSASRSRSPTSRDLKHKREEYIKKISETSLFA 556
              |..::.:|..       .||.|:: |||.|.|:.|.|.|....:.:.:.||.....||.|...
  Rat   253 --REEKVEERDLLSDLQDISDSERKT-SSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEE 314

  Fly   557 ELVKDRHKR-----------QKALKEII--ERQEENSNSNSNGALTINDNSSSVDGNTPNAADGR 608
            |..::..:.           :::.:|:.  |..|:....|.|..|.:.:  |..|.::.::.:|.
  Rat   315 EEEEEEEEEEETGSNSEEASEQSAEEVSDEEMSEDEDRENENHILVVPE--SRFDRDSGDSDEGE 377

  Fly   609 SAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLV 673
            ...|.|||.:::.|                       :.|.|..:||.      |..:|||.|
  Rat   378 EEVGEGTPQSSAPT-----------------------EGDYVPDSPAL------SPIELKQEL-- 411

  Fly   674 PPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTSSGSANKSVLNLPMPP 738
                       ||.|.:|.
  Rat   412 -----------PKYLPALQ---------------------------------------------- 419

  Fly   739 VIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCVDV 803
                                                                      |.|.|:.
  Rat   420 ----------------------------------------------------------GCRSVEE 426

  Fly   804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHE 868
            |:.:.:|.|||||.||:|:|..|:::||||::::|.||||||||::|||..:.:..|.|||.:.|
  Rat   427 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVRE 491

  Fly   869 IVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFL 933
            ||      |....||  .|:|..|::|||..|:|:....|......::|.|||.|:.:.|....|
  Rat   492 IV------VGSNMDK--IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWIL 548

  Fly   934 HRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVW 998
            |||:|.||:|:::.|.:|:.||||||.|.:.  .:.||..|:|||||.||||||.:.|..::|:|
  Rat   549 HRDLKTSNLLLSHAGILKVGDFGLAREYGSP--LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMW 611

  Fly   999 SCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLRED 1063
            |.|||.|||..::|||...:|:.|:..:.|..|:|...:||....||....:...:.....||:.
  Rat   612 SVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKR 676

  Fly  1064 F-EFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTP----QLPTWQDCHELWSK 1123
            | ..:.....||::|.|...|.:|::|||.|:..:.|     |.|.|    ..|||.      :|
  Rat   677 FGALLSDQGFDLMNKFLTYFPGRRVSAEDGLKHEYFR-----ETPLPIDSSMFPTWP------AK 730

  Fly  1124 KRRRQMREQQESLPPTVIASTKYQQHG 1150
            ..:::::......||.  ....|.|.|
  Rat   731 SEQQRVKRGTSPRPPE--GGLGYSQLG 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	122/302 (40%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	119/294 (40%)
Cdk11b	NP_665709.2	STKc_CDC2L1	421..712	CDD:173741	121/300 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920