Protein Alignment Cdk12 and cdk-11.2

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_509746.2
• Gene: cdk-11.2 / 181247
• WormBaseID: WBGene00013917
• Length: 668
• Species: Caenorhabditis elegans
• Alignment Length: 740
• Identity: 197/740 - (26%)
• Similarity: 329/740 - (44%)
• Gaps: 159/740 - (21%)

  Fly   451 SHTTRTSKRASGTGTSGD----RYSRSPRTS-----SRYMESSPPSPVGASGSHHYHH---RRSP 503
            :::|..|::...:.:..|    |:|..||.|     .||.:..      ....|..||   ||..
 Worm     3 NYSTNGSRKIRISNSDDDSRETRFSIQPRNSHKTKEERYRDKE------KERDHERHHDRERRDD 61

  Fly   504 RMRQ---RTRGDSRRRSPSSASSESSASRSRSPTSRDLKHKREEYIKKISETSLFAELVKDRHKR 565
            |.|:   |...|..||||:.         ||:....:...:|..:              .||::|
 Worm    62 RYRKVDSRDHRDRNRRSPAG---------SRTYCRDEPDRRRNNH--------------SDRNRR 103

  Fly   566 QKALKEIIERQEENSNSNSNGALTINDNSSSVDGNTPNAADGRSAPGSGTPAAASTTSNGLQALG 630
            .::    .||..:|.:|.|.             ..:|::...:|:..|.||
 Worm   104 DRS----SERDRDNRSSKSK-------------TKSPDSLRSKSSRKSQTP-------------- 137

  Fly   631 SKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNNIKPKSLTSLPLPP 695
                   |::|...|..|.::.......:  .:|.:::...:.|.....:..:...:..
 Worm   138 -------NHLPDDGKLFDRILDPNYKKKE--KTVMEVEDVEMSPVEMLDEEEVSTFTFD------ 187

  Fly   696 GMNVLDLAGARSPSPGQKKESDEKNVTSSG--SANKSVLNLPMPP------VIPGSEELSGDDDV 752
                 |..|...||    .|.:||:..|.|  .:..:....|:.|      ::..:|.||.|:|
 Worm   188 -----DACGPVRPS----NEPEEKDYKSEGDPESRPATPKTPLTPDYLENTIVSLNETLSDDED- 242

  Fly   753 IDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILN----RRDSRNNVRDWGER-------------- 799
             ..|:|          .:|..|...:...:..|    .||:....|:...|
 Worm   243 -KGPDD----------KYGKTPDKEQWESMTENEQKLHRDAMKKRREQRHREAVSKLPVYYPGLR 296

  Fly   800 -CVDVFE--MIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLN-H 860
             |..:.|  ::..|.|||||:|::.::..|:::||||:.::|.|||||||||:|||.:|.:.. |
 Worm   297 GCQHISEYVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINMLLKAGAH 361

  Fly   861 RNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLE---SGMVDFNEENNASIMKQLLD 922
            .||||:.||:..        ..|...|:..||::||:..|::   |....|......::|.|||.
 Worm   362 ENIVNVKEILVG--------STKTEVYMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLS 418

  Fly   923 GLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLY-NADDRER--PYTNKVITLWYRPPEL 984
            |:.:.||...||||:|.||:|:::.|.:|:|||||||.| .|.|.|:  ..|..|:|||||.|||
 Worm   419 GIEHMHKLWILHRDLKTSNLLISHSGILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRSPEL 483

  Fly   985 LLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHT 1049
            ||..:.|...:|:||.|||:.|..:.:|:||.::|..|:..|.::.|:|...:||::.:|.:::.
 Worm   484 LLEPKTYSTPVDMWSIGCIMAEFIMMKPMFQGDSEPNQVHQIFQMMGTPTEQIWPDIKELKVWNM 548

  Fly  1050 LK---QKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQL 1111
            ::   .|....||:.:..:.:.....|||:.||.|:|..|:||.:||:..|..: :|..:|...|
 Worm   549 VEFPPVKPGQLRRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQHDWFSE-HPKAVPPEDL 612

  Fly  1112 PTWQDCHELWSKKRRRQMREQQESL 1136
            |.:....||.:.....:.:.:.|:|
 Worm   613 PVYPAKSELNAAPPENRRKNRLEAL 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	119/328 (36%)
cdk-11.2	NP_509746.2	Protein Kinases, catalytic domain	298..600	CDD:473864	118/309 (38%)